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    1. Physics of Living Systems
    2. Neuroscience

    Physical limits to magnetogenetics

    Markus Meister
    Recent reports on the ability of biological molecules to sense magnetic fields are found to be inconsistent with basic physical principles.
    1. Cell Biology

    Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites

    Wei-ke Ji et al.
    A key cellular process is controlled by altering a balance, rather than through an off/on mechanism.
    1. Neuroscience

    An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans

    Yu Shen et al.
    The activity of a set of GABAergic neurons is causally linked with a locomotory pattern in moving animals, and the mechanisms underlying the neuromodulatory role of GABA are illuminated.
    1. Neuroscience

    AMPK acts as a molecular trigger to coordinate glutamatergic signals and adaptive behaviours during acute starvation

    Moloud Ahmadi, Richard Roy
    AMP-activated protein kinase directly coordinates glutamatergic signalling during starvation in C. elegans.
    1. Neuroscience

    Functional integration of a serotonergic neuron in the Drosophila antennal lobe

    Xiaonan Zhang, Quentin Gaudry
    Serotonergic cells innervating the Drosophila antennal lobe are inhibited by odors and modulate olfactory responses in conjunction with the entire serotonergic network.
    1. Neuroscience

    Thalamic reticular nucleus induces fast and local modulation of arousal state

    Laura D Lewis et al.
    A neural circuit that can selectively induce sleep-like patterns in small regions of the brain demonstrates how sleep and arousal states may be controlled in local brain regions.
    1. Computational and Systems Biology
    2. Neuroscience

    Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit

    Marianne J Bezaire et al.
    Spontaneous theta oscillations and interneuron-specific phase preferences emerge spontaneously in a full-scale model of the isolated hippocampal CA1 subfield, corroborating and extending recent experimental findings.
    1. Neuroscience

    Inhibitory control of correlated intrinsic variability in cortical networks

    Carsen Stringer et al.
    A new cortical network model fit directly to multi-neuron recordings reveals that local inhibitory feedback can control neural dynamics, modulate brain state and enhance sensory processing.
    1. Neuroscience

    Cellular and neurochemical basis of sleep stages in the thalamocortical network

    Giri P Krishnan et al.
    A computational model of the thalamocortical network explains sleep stages by the coordinated variations in the level of neuromodulators and predicts differences of sleep pattern in human, cat and mouse recordings.
    1. Neuroscience

    Transformation of spatiotemporal dynamics in the macaque vestibular system from otolith afferents to cortex

    Jean Laurens et al.
    The spatial and dynamic properties of self-motion signals are acquired at the first stage of otolith signal transformation, which is in the brainstem and cerebellum, and conserved across brainstem, cerebellar and cortical areas.