193 results found
    1. Neuroscience

    Excitation of medium spiny neurons by ‘inhibitory’ ultrapotent chemogenetics via shifts in chloride reversal potential

    Stephanie C Gantz et al.
    Modifying membrane potential by an 'inhibitory' chloride conductance such as PSAM4-GlyR is inherently unstable because the normally low intracellular concentration of chloride is readily increased by influx of chloride.
    1. Cell Biology

    Pre-complexation of talin and vinculin without tension is required for efficient nascent adhesion maturation

    Sangyoon J Han et al.
    Pre-complexation of vinculin with talin’s R8 domain facilitates nascent adhesion maturation by unfolding talin, increasing vinculin binding, and thereby transmitting traction forces to the environment.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

    Nandish Khanra et al.
    Structures of the GluK2/K5 kainate receptor reveal the heteromer architecture and how the receptor organizes in apo, antagonist-bound, and desensitized states.
    1. Developmental Biology
    2. Neuroscience

    Targeted molecular profiling of rare olfactory sensory neurons identifies fate, wiring, and functional determinants

    J Roman Arguello et al.
    Targeted expression of molecular probes for gene expression and chromatin accessibility in subpopulations of neurons in the Drosophila olfactory system identifies genes required for their development and function.
    1. Neuroscience

    Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry

    Gregory G Grecco et al.
    A novel, translational mouse model of prenatal methadone exposure was developed and a longitudinal assessment of offspring revealed impairments in physical, behavioral, and neuronal development.
    1. Developmental Biology
    2. Neuroscience

    NMDA receptors control development of somatosensory callosal axonal projections

    Jing Zhou et al.
    NMDAR receptors act in regulating axon guidance of somatosensory callosal projections in early postnatal life and the expression of EPHB2 receptors in target cells.
    1. Neuroscience

    Brain endothelial cell TRPA1 channels initiate neurovascular coupling

    Pratish Thakore et al.
    Activation of TRPA1 channels on cerebral capillary endothelial cells initiates a retrograde signal that propagates and dilates upstream arterioles.
    1. Neuroscience

    Incomplete removal of extracellular glutamate controls synaptic transmission and integration at a cerebellar synapse

    Timothy S Balmer et al.
    Extracellular levels of the neurotransmitter glutamate are maintained at physiologically significant levels at some synapses even in the absence of action potentials.
    1. Neuroscience

    Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila

    Colleen N McLaughlin et al.
    Single-cell transcriptomes of olfactory receptor neurons at multiple developmental stages reveal cell-type-specific gene expression programs that underlie their development and sensory biology.
    1. Neuroscience

    The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle

    Carlos Manlio Díaz-García et al.
    When neurons are stimulated, calcium entry into mitochondria upregulates mitochondrial energy production, but glycolytic energy production in the cytosol is stimulated by elevated energy demand, not Ca2+ signaling.

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