352 results found
    1. Neuroscience

    Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in Drosophila

    Zachary A Knecht et al.
    A combination of genetics, behavior and physiology demonstrate that cool and moisture sensing rely on overlapping combinations of sensory receptors in Drosophila.
    1. Neuroscience

    Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila

    Zachary A Knecht et al.
    The neurons and receptors mediating moist air detection in Drosophila are identified, revealing that moist and dry air detection depend on overlapping Ionotropic Receptors and that these pathways are both critical for hygrosensation.
    1. Neuroscience

    Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo

    Jin Bao et al.
    During parallel fibre activity in vivo, postsynaptic mGluR1 receptors in molecular layer interneurons of the cerebellar cortex are engaged in a frequency-dependent manner and in concert with inotropic glutamate receptors.
    1. Neuroscience

    Molecular basis of fatty acid taste in Drosophila

    Ji-Eun Ahn et al.
    Molecular-genetic, neural imaging and behavioral analyses reveal how Drosophila melanogaster sense fatty acids, important nutrient compounds, through multimeric Ionoptropic Receptors complexes.
    1. Neuroscience

    The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila

    Lina Ni et al.
    Two members of a widely studied family of chemoreceptors, the "orphan" chemoreceptor IR21a and its putative co-receptor IR25a, act together to mediate cool sensation in fruit fly larvae.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology

    Damien Lemoine et al.
    A photoswitchable pore blocker was covalently attached to a cysteine-substituted glutamate delta 2 receptor, to provide optical control of its ion channel function.
    1. Cell Biology
    2. Neuroscience

    CRELD1 is an evolutionarily-conserved maturational enhancer of ionotropic acetylcholine receptors

    Manuela D'Alessandro et al.
    The protein disulphide isomerase CRELD1 controls the biosynthesis of nicotinic acetylcholine receptors in nematode and mouse muscle.
    1. Evolutionary Biology
    2. Neuroscience

    Glutamate Receptors: Family matters

    Mark L Mayer, Timothy Jegla
    Genome sequence data from a range of animal species are raising questions about the origins of glutamate receptors.
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    1. Evolutionary Biology
    2. Neuroscience

    Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events

    David Ramos-Vicente et al.
    The animal phylogeny of glutamate receptors indicates that vertebrate types do not account for all receptor classes originated during evolution, neither are they the pinnacle of a linear evolutive process.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Auxiliary subunits keep AMPA receptors compact during activation and desensitization

    Jelena Baranovic, Andrew JR Plested
    The auxiliary protein Stargazin limits the conformational dynamics of AMPA-type glutamate receptors in cell membranes, as revealed by 'molecular rulers' deployed on the seconds to milliseconds timescale.

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