645 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release

    Jeffrey T Lock, Ian Parker
    Cell-wide Ca2+ signals that regulate numerous cellular functions comprise dual Ca2+ release modes through IP3 receptors, punctate transients mediated by clustered receptors and spatiotemporally diffuse release through functionally distinct receptors.
    1. Cell Biology

    Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3

    Dianrong Li et al.
    Casein kinase 1G2 interacts with and inhibits the activation of receptor-interacting kinase 3, RIP3, in response to TNF and toll-like receptor family members and attenuates its necroptosis signaling activity.
    1. Medicine

    Drug Discovery: From worms to fish to mice

    Guy M Benian, Hyojung J Choo
    An multi-species approach can be used to identify small molecules with properties that might prove useful for the treatment of some neuromuscular diseases.
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    1. Neuroscience

    A circuit mechanism for decision-making biases and NMDA receptor hypofunction

    Sean Edward Cavanagh et al.
    Ketamine, an NMDA receptor antagonist and experimental model for schizophrenia, produces decision-making deficits in monkeys, which are predicted by a lowering of cortical excitation-inhibition balance in a spiking circuit model.
    1. Plant Biology

    The manifold actions of signaling peptides on subcellular dynamics of a receptor specify stomatal cell fate

    Xingyun Qi et al.
    A binary cell fate decision to be or not to be stomata is regulated by multiple peptide ligands, each triggering a unique subcellular dynamics of their shared receptor.
    1. Cell Biology
    2. Neuroscience

    Ubiquitin-interacting motifs of ataxin-3 regulate its polyglutamine toxicity through Hsc70-4-dependent aggregation

    Sean L Johnson et al.
    Pathogenesis in Spinocerebellar Ataxia Type 3 is enhanced by the heat-shock protein family member, Hsc70-4, uncovering new mechanisms of toxicity for this disease and suggesting pleiotropic roles for chaperones.
    1. Neuroscience

    Vascular control of the CO2/H+-dependent drive to breathe

    Colin M Cleary et al.
    Understanding how loss of CO2/H+ vascular reactivity affects respiratory control may facilitate development of treatments for breathing problems in this population.
    1. Microbiology and Infectious Disease

    CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

    Kui Xu et al.
    The double-gene-knockout pig is a valuable model to help understand the mechanisms of CD163 and pAPN in the infection of multiple viruses and offers excellent breeding materials for disease-resistant pigs.
    1. Microbiology and Infectious Disease

    Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

    Suneeta Chimalapati et al.
    Considering the course of a pathogen's evolution, there appears to be interplay between secretion systems, providing unique, synergistic mechanisms to support a successful lifestyle for possibly pathogenesis, symbiosis and/or parasitosis.

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