359 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion

    Viktoria Désirée Paul et al.
    Two newly identified assembly factors for the ribosome-associated iron-sulfur protein Rli1 reveal a general mechanism for how the cytosolic iron-sulfur protein assembly (CIA) machinery recruits apoproteins.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins

    Marta A Uzarska et al.
    Cell biological, biochemical and structural studies reveal the mechanistic roles of two new mitochondrial iron-sulfur protein assembly factors, explaining the patho-biochemical defects of affected patients.
    1. Biochemistry and Chemical Biology

    The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis

    Jonathan G Van Vranken et al.
    The essential function of ACP is not related to mitochondrial fatty acid and lipoic acid synthesis, but rather an evolutionarily-conserved role in iron sulfur cluster biogenesis.
    1. Biochemistry and Chemical Biology

    Mechanisms of iron- and O2-sensing by the [4Fe-4S] cluster of the global iron regulator RirA

    Ma Teresa Pellicer Martinez et al.
    Molecular details of how the iron–sulfur cluster cofactor of a bacterial global iron regulatory protein simultaneously senses iron and O2 are revealed by mass spectrometry and spectroscopy.
    1. Biochemistry and Chemical Biology

    Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients

    Andrew Melber et al.
    Mitochondrial proteins Nfu1 and BolA3 mediate the transfer of preformed [4Fe-4S] clusters within the mitochondria to recipient proteins to shield clusters from oxidative damage during transfer.
    1. Cell Biology

    The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster

    Guiran Xiao et al.
    Drosophila ZIP13 (Slc39a13), a presumed zinc importer, is responsible for iron delivery to the secretory pathway.
    1. Structural Biology and Molecular Biophysics

    Functional asymmetry and electron flow in the bovine respirasome

    Joana S Sousa et al.
    Cryo-EM structure of the mammalian respiratory supercomplex containing complexes I, III and IV shows a functional asymmetry of complex III, providing strong evidence for directed electron flow in the respirasome.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Catalysis-dependent selenium incorporation and migration in the nitrogenase active site iron-molybdenum cofactor

    Thomas Spatzal et al.
    Unanticipated rearrangements in the nitrogenase active site establish the dynamic nature of the FeMo-cofactor during catalysis.
    1. Structural Biology and Molecular Biophysics

    A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore

    Priscilla S-W Yeung et al.
    Electrophysiological and molecular modeling studies identify a sulfur-aromatic interaction between the hydrophobic channel gate and a nearby methionine residue, termed the "gate latch", which is essential for Orai1 pore opening.

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