The structure of the human iron exporter ferroportin in complex with its inhibitor vamifeport, which is currently in clinical development against β-thalassemia and sickle cell disease, provides insight into pharmacological mechanisms.

Drosophila ZIP13 (Slc39a13), a presumed zinc importer, is responsible for iron delivery to the secretory pathway.

The lack of haem biosynthetic and degradative pathways in ticks offers new strategies to combat these parasites.

Bioinformatic and biochemical studies provide evidence that covalently bound flavins are common and participate in wide-ranging extracytosolic redox activities throughout bacterial life.

Staphylococcal heme acquisition needs a highly structured cell envelope, the membrane transporter accumulates in membrane domains most likely to allow concerted passage of heme from the cell wall-funnel to the membrane.

An alternative iron storage system based on a 9.6 megadalton microbial protein compartment is able to sequester and store large amounts of iron.

Iron content in neural stem cells controlled by glial ferritin is critical for self-renewal and proliferation of neural stem cells.

An iron-sensitive gene cluster encodes proteins that co-localize with phytotransferrin endosomes and are involved in key intracellular iron transformation and trafficking processes in a model marine diatom.

Cryo-EM structure and functional analyses show that human iron exporter ferroportin (Fpn) can bind and transport calcium ions and the transport activity is reduced when the concentration of ferrous ions is high.

The novel role of hepcidin in cell-autonomous iron regulation changes our understanding of tissue-specific iron control, and of its interplay with systemic iron homeostasis.