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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Large protein organelles form a new iron sequestration system with high storage capacity

    Tobias W Giessen et al.
    An alternative iron storage system based on a 9.6 megadalton microbial protein compartment is able to sequester and store large amounts of iron.
    1. Biochemistry and Chemical Biology

    Mechanisms of iron- and O2-sensing by the [4Fe-4S] cluster of the global iron regulator RirA

    Ma Teresa Pellicer Martinez et al.
    Molecular details of how the iron–sulfur cluster cofactor of a bacterial global iron regulatory protein simultaneously senses iron and O2 are revealed by mass spectrometry and spectroscopy.
    1. Computational and Systems Biology
    2. Neuroscience

    Mapping the function of neuronal ion channels in model and experiment

    William F Podlaski et al.
    The ion channel genealogy resource is a comprehensive and intuitive comparison tool for ion channel models and experimental data, helping to visualize their similarity and function to facilitate better experimentally-constrained modeling.
    1. Neuroscience

    Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals

    Kuchuan Chen et al.
    The iron/sphingolipid/PDK1/Mef2 pathway is activated in mammals upon loss of Frataxin.
    1. Cell Biology

    The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster

    Guiran Xiao et al.
    Drosophila ZIP13 (Slc39a13), a presumed zinc importer, is responsible for iron delivery to the secretory pathway.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Sculpting ion channel functional expression with engineered ubiquitin ligases

    Scott A Kanner et al.
    Engineered E3 ubiquitin ligases are utilized to elucidate mechanisms underlying ubiquitin regulation of membrane proteins, and to achieve robust post-translational functional knockdown of ion channels.
    1. Genetics and Genomics
    2. Neuroscience

    The ion channel ppk301 controls freshwater egg-laying in the mosquito Aedes aegypti

    Benjamin J Matthews et al.
    The ion channel ppk301 is required for the evaluation of water purity during egg-laying, which promotes offspring survival in the arboviral vector mosquito Aedes aegypti.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

    Swetha E Murthy et al.
    A family of proteins (OSCA/TMEM63) that encode mechanosensitive ion channels has been characterized in plants, flies, and mammals.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in Chlamydia trachomatis

    Nick D Pokorzynski et al.
    Analysis of the atypical tryptophan biosynthetic operon of Chlamydia trachomatis revealed the simultaneous regulation of transcriptional initiation and termination by an iron-dependent repressor, expanding known regulatory mechanisms of this pathway.
    1. Cell Biology

    Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

    Joseph D Mancias et al.
    NCOA4, the ferritin autophagy receptor, is regulated by HERC2 in an iron-dependent manner and is critical for red blood cell development.