87 results found
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

    Gaspare La Rocca et al.
    A new genetically engineered mouse strain is described in which miRNA activity can be acutely and reversibly inhibited, showing that in a subset of adult tissues miRNA activity is dispensable under homeostatic conditions but becomes essential during tissue regeneration.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells

    Bo-Ruei Chen et al.
    The LIN37-DREAM complex has a critical role in regulating DNA double-strand break end processing and suppressing aberrant homology-directed repair in quiescent cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

    Isabelle J Marié et al.
    Overlapping action of type I, II, and III interferons maintains microbiome homeostasis, prevents IL-17-driven myeloproliferative disease, and protects against inflammatory bowel disease.
    1. Ecology

    How will mosquitoes adapt to climate warming?

    Lisa I Couper et al.
    Mosquitoes may be likely to adapt to climate warming given their short life cycles and strong temperature sensitivity, but key data gaps identified here constrain current estimates of adaptive potential.
    1. Cell Biology
    2. Computational and Systems Biology

    Highly localized intracellular Ca2+ signals promote optimal salivary gland fluid secretion

    Takahiro Takano et al.
    Measurement of physiological intracellular Ca2+ signals following neural stimulation in vivo reveals distinct spatiotemporal characteristics that promote optimal salivary gland fluid secretion.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    AAV ablates neurogenesis in the adult murine hippocampus

    Stephen Johnston et al.
    Future work using recombinant AAV as an experimental tool in the dentate gyrus or as a gene therapy for diseases of the central nervous system should be carefully evaluated.
    1. Cell Biology
    2. Developmental Biology

    Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

    Patricia Giselle Cipriani et al.
    Two novel LOTUS-domain proteins are core germ granule components that directly recruit Caenorhabditis elegans Vasa, regulate germ granule size and localization, and provide an organizational framework for ribonucleoprotein complexes.
    1. Microbiology and Infectious Disease

    A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

    Dayana C Farhat et al.
    The epitranscriptomic-driven mRNA polyadenylation pathway protects transcriptome integrity by restricting transcriptional read-throughs and RNA chimera formation in apicomplexan parasites and plants.
    1. Stem Cells and Regenerative Medicine

    Distinct skeletal stem cell types orchestrate long bone skeletogenesis

    Thomas H Ambrosi et al.
    Functional and molecular analyses of two distinct skeletal stem cell populations establish the important role of stem cell diversity that provides a framework for novel investigations into skeletal biology.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

    Máté Nászai et al.
    Combined genetic experiments and cellular trafficking assays in Drosophila and mammalian models uncover a new role of RAS-like GTPases in EGFR signalling activation during tissue regeneration and tumourigenesis through regulation of EGFR internalisation.

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