Patients diagnosed with a cardiovascular disease are at higher risk of psychiatric disorders, independent of familial factors shared between full siblings and comorbid conditions.
Mapping the fate of clogged brain capillaries reveals that VEGF signaling plays a critical role in dictating whether capillaries regain blood flow and persist or are pruned from the vascular tree.
Gabriel L McKinsey, Carlos O Lizama ... Thomas D Arnold
P2ry12-CreER robustly and specifically labels microglia in fate-mapping and ribosomal profiling experiments, revealing new markers for myeloid subpopulations in the central nervous system.
The proportional recovery rule, an apparently simple model that nonetheless requires careful statistical treatment, remains an important biological and predictive framework for stroke recovery.
Savannah F Bifulco, Griffin D Scott ... Patrick M Boyle
In models reconstructed from MRI scans of patients with embolic stroke of undetermined source, computational simulations reveal that fibrosis has the intrinsic capacity to sustain arrhythmia drivers when subjected to triggered activity known to exist in patients with atrial fibrillation.
Cumulatively, from 1950 to 2015, smoking-related disease has been the biggest cause of premature death in high-income countries, with elevated risks of smoking continuing well into the 21st century.
The number of inflows and outflows at the occluded capillary governs the local flow reduction, and the different topological configurations are probably designed for distinct functional tasks.
Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.
