7,981 results found
    1. Neuroscience

    Sexually dimorphic neuronal responses to social isolation

    Laura Senst et al.
    Male and female mice react differently to social isolation but not to an acute physical stress.
    1. Microbiology and Infectious Disease

    Revisiting the guidelines for ending isolation for COVID-19 patients

    Yong Dam Jeong et al.
    Compared with the approach isolating COVID-19 patients for a fixed period, the approach using repeated PCR testing mitigates unnecessarily lengthy isolation of patients while minimizing the risk of further transmission.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Transcription mediated insulation and interference direct gene cluster expression switches

    Tania Nguyen et al.
    The formation of mutually exclusive coding and non-coding transcription units contributes to transcriptional interference and insulation at gene clusters and manages state-switching in response to environmental change.
    1. Cancer Biology

    Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation

    Yogev Sela et al.
    A photoconversion-based isolation technique enables systematic investigation of spatially distinct small metastases (microcolonies) versus large lesions (macrometastases).
    1. Genetics and Genomics
    2. Neuroscience

    Probe-Seq enables transcriptional profiling of specific cell types from heterogeneous tissue by RNA-based isolation

    Ryoji Amamoto et al.
    Probe-Seq is a cell type specific bulk RNA sequencing method that can be applied to a wide-ranging tissue types from both vertebrates and invertebrates without genetic labeling.
    1. Neuroscience

    Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels

    Derya Sargin et al.
    Serotonin neurons in chronically isolated mice become less responsive to excitatory stimulation, but inhibiting a distinctive calcium-activated potassium channel can restore both neuronal activity and behavior.
    1. Neuroscience

    Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners

    Hande Tunbak et al.
    Social isolation increases anti-social behaviour by altering activity in brain areas related to anxiety, stress, and reward.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution

    Michael Luke Carlson et al.
    A simple, yet elegant method for robust self-assembly of diverse membrane proteins into soluble peptide nanoparticles for their structural and functional analysis in detergent-free solutions.
    1. Structural Biology and Molecular Biophysics

    Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states

    Rahul Chadda et al.
    Differences in the lipid solvation energetics of associated and dissociated states is a primary driving force for membrane protein oligomerization, presenting a molecular mechanism for lipid regulation in biology.
    1. Medicine

    Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO

    Naga Suresh Adapala et al.
    Site-specific modification of NEMO facilitates RANKL signal specificity in myeloid progenitors and serves as a potential target to modulate inflammatory osteolysis through ISG15-dependent autophagy.

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