179 results found
    1. Medicine
    2. Immunology and Inflammation

    A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies

    Thomas Balligand, Claire Carpenet ... Maarten Dewilde
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Ecology
    2. Evolutionary Biology

    Passive accumulation of alkaloids in inconspicuously colored frogs refines the evolutionary paradigm of acquired chemical defenses

    Rebecca D Tarvin, Jeffrey L Coleman ... Richard W Fitch
    The detection of low quantities of alkaloids in putatively nontoxic species of poison frogs sheds light on early evolutionary stages of chemical defense in animals.
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    Prebiotic Gas Flow Environment Enables Isothermal Nucleic Acid Replication

    Philipp Schwintek, Emre Eren ... Dieter Braun
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cell Biology
    2. Neuroscience

    An acute microglial metabolic response controls metabolism and improves memory

    Anne Drougard, Eric H Ma ... John Andrew Pospisilik
    High-fat ingestion triggers microglial metabolic activation within a single feeding cycle, and enhances whole-body metabolism and memory by converting fatty acids into protective substrates for surrounding neurons.
    1. Microbiology and Infectious Disease

    Staphylococcus aureus counters organic acid anion-mediated inhibition of peptidoglycan cross-linking through robust alanine racemase activity

    Sasmita Panda, Yahani P Jayasinghe ... Vinai C Thomas
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Convincing
    1. Cell Biology
    2. Cancer Biology

    N6-methyladenosine in DNA promotes genome stability

    Brooke A Conti, Leo Novikov ... Mariano Oppikofer
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Reassessing the substrate specificities of the major Staphylococcus aureus peptidoglycan hydrolases lysostaphin and LytM

    Lina Antenucci, Salla Virtanen ... Perttu Permi
    Robust NMR approach allowed simultaneous detection of substrate cleavage site and real-time kinetics of hydrolysis for Staphylococcus aureus peptidoglycan hydrolases lysostaphin and LytM, and revealed D-alanyl-glycine activity for LytM.
    1. Neuroscience

    DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

    Ernie Yulyaningsih, Jung H Suh ... Pascal E Sanchez
    DNL343, a brain-penetrant integrated stress response inhibitor, reduces neurodegeneration in mouse models and identifies biomarker candidates for assessing treatment responses in clinical settings.
    1. Structural Biology and Molecular Biophysics

    Atomistic Tuning of the GeoCas9 Recognition Lobe Modulates Allosteric Motions and Guide RNA Interactions

    Helen B Belato, Alexa L Knight ... George P Lisi
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages

    Timothy A Bates, Mila Trank-Greene ... Fikadu G Tafesse
    ESAT-6, a virulence factor of Mycobacterium tuberculosis, dimerizes at neutral pH and transitions to oligomers under acidic pH similar to that of lysosome, helping the bacterium evade host defense mechanisms.
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