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    1. Ecology

    Using aquatic animals as partners to increase yield and maintain soil nitrogen in the paddy ecosystems

    Liang Guo, Lufeng Zhao ... Xin Chen
    Aquatic animals cocultured with rice in paddy ecosystems can increase food production, improve nitrogen (N)-use efficiency, and maintain soil fertility by reducing weeds, and promoting recycle and complementary use of N.
    1. Neuroscience

    Cortical tau deposition follows patterns of entorhinal functional connectivity in aging

    Jenna N Adams, Anne Maass ... William J Jagust
    Tau deposition in the aging brain follows patterns of functional connectivity that correspond to specific neural memory networks, and this relationship is strengthened in the presence of amyloid-β.
    1. Microbiology and Infectious Disease

    Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis

    Aleksandra Agapova, Agnese Serafini ... Luiz Pedro Sório de Carvalho
    Metabolomics and stable isotope labelling studies of virulent Mycobacterium tuberculosis reveal a de-centralised metabolic network able to utilise various amino acids as nitrogen sources to a better extent than ammonium.
    1. Cancer Biology

    Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

    Alexander Muir, Laura V Danai ... Matthew G Vander Heiden
    Cell culture models widely used in cancer research do not reflect metabolism in tumors; by altering culture systems to better model tumor metabolism we find that environmental cystine promotes tumor glutamine metabolism.
    1. Ecology
    2. Microbiology and Infectious Disease

    Transparent soil microcosms for live-cell imaging and non-destructive stable isotope probing of soil microorganisms

    Kriti Sharma, Márton Palatinszky ... Elizabeth A Shank
    Two optically transparent substrates enable the exploration of the ecophysiology and spatiotemporal organization and activities of bacteria and fungi within heterogeneous soil-like environments.
    1. Biochemistry and Chemical Biology

    Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

    Matthew A Mitsche, Jeffrey G McDonald ... Jonathan C Cohen
    Cells use two interdigitated biosynthetic pathways that can be regulated independently to produce diverse bioactive sterols.
    1. Ecology
    2. Microbiology and Infectious Disease

    Subcellular tracking reveals the location of dimethylsulfoniopropionate in microalgae and visualises its uptake by marine bacteria

    Jean-Baptiste Raina, Peta L Clode ... David G Bourne
    The intracellular location of a key sulfur compound, dimethylsulfoniopropionate, was identified in microalgae and its subsequent uptake by marine bacteria was quantified using a combination of secondary-ion mass-spectrometry techniques.
    1. Ecology

    Microplankton life histories revealed by holographic microscopy and deep learning

    Harshith Bachimanchi, Benjamin Midtvedt ... Giovanni Volpe
    The combination of holographic microscopy and deep learning provides a revolutionary tool for plankton ecology that will permit researchers to observe and study the life, feeding habits and reproduction of plankton with unprecedented detail.
    1. Biochemistry and Chemical Biology

    Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach

    Xiucong Bao, Yi Wang ... Xiang David Li
    Sirt3 functions as decrotonylase to regulate histone crotonylation dynamics.
    1. Evolutionary Biology

    The age of Homo naledi and associated sediments in the Rising Star Cave, South Africa

    Paul HGM Dirks, Eric M Roberts ... Lee R Berger
    Independent dating techniques have established that the H. naledi fossils are between 236 and 335 thousand years old, indicating that small-brained hominins with relatively primitive body shapes co-existed with our early ancestors in Africa.