14,728 results found
    1. Epidemiology and Global Health

    A century of trends in adult human height

    NCD Risk Factor Collaboration (NCD-RisC)
    Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.
    1. Microbiology and Infectious Disease

    An intestinally secreted host factor promotes microsporidia invasion of C. elegans

    Hala Tamim El Jarkass, Calvin Mok ... Aaron W Reinke
    A forward genetic screen in Caenorhabditis elegans identifies a secreted host protein that ensures proper microsporidia spore orientation, resulting in efficient invasion of intestinal cells.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    A new view of transcriptome complexity and regulation through the lens of local splicing variations

    Jorge Vaquero-Garcia, Alejandro Barrera ... Yoseph Barash
    New methods reveal that complex local splicing variations are more prevalent in animals than previously appreciated, and demonstrate that local splicing variations are relevant for studies of development, gene regulation and neurodegenerative diseases.
    1. Cancer Biology
    2. Cell Biology

    Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy

    Leying Chen, Qing You ... Shiyi Zhang
    Modulation of dermal adipocytes contributes to skin homeostasis and provides a promising new therapeutic strategy in the treatment of EGFRI-related skin disorders.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Self-assembling manifolds in single-cell RNA sequencing data

    Alexander J Tarashansky, Yuan Xue ... Bo Wang
    An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption

    Chenlu Zhang, Zehan Hu ... Tamia A Harris-Tryon
    SPRRs are bactericidal proteins, stimulated in the sebaceous gland by lipopolysaccharide, that defend the host against infection through bacterial membrane binding and disruption.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The Dantu blood group prevents parasite growth in vivo: Evidence from a controlled human malaria infection study

    Silvia N Kariuki, Alexander W Macharia ... Thomas N Williams
    Strongly protective effect conferred by the Dantu blood group variant against early, non-clinical, Plasmodium falciparum malaria infections in vivo.
    1. Cell Biology
    2. Medicine

    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

    Thao DV Le, Dianxin Liu ... Julio E Ayala
    The ability of the therapeutic glucagon-like peptide-1 receptor agonist liraglutide to promote weight loss is partly dependent on signaling via PKA-dependent phosphorylation of the mTORC1 regulator protein Raptor.
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of the 90S small subunit pre-ribosome

    Qi Sun, Xing Zhu ... Keqiong Ye
    The nearly complete architecture of the gigantic 90S precursor of small ribosomal subunit is determined by cryo-EM.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Transcription inhibition by the depsipeptide antibiotic salinamide A

    David Degen, Yu Feng ... Richard H Ebright
    Salinamide A exerts antibacterial activity by binding to the bridge-helix cap of bacterial RNA polymerase and allosterically inhibiting nucleotide addition

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