673 results found
    1. Neuroscience

    Across-species differences in pitch perception are consistent with differences in cochlear filtering

    Kerry MM Walker et al.
    Humans and other animals have different strategies for extracting the pitch of sounds, potentially driven by the species-specific frequency selectivity of the ear.
    1. Neuroscience

    Identification of a bilirubin receptor that may mediate a component of cholestatic itch

    James Meixiong et al.
    MRGPRX4 is a bilirubin receptor that may be a therapeutic target for patients suffering from cholestatic itch.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons

    Pedro L Martinez-Espinosa et al.
    Sodium-activated potassium ion currents encoded by the kcnt1 gene delay action potential firing in DRG neurons by activity preceding an action potential.
    1. Neuroscience

    A zebrafish and mouse model for selective pruritus via direct activation of TRPA1

    Kali Esancy et al.
    A pain-relaying ion channel on a hypersensitive population of sensory neurons can instead elicit sensations of itch in both fish and mice when directly activated, providing a novel model of itch transduction.
    1. Cell Biology

    Structure of cellular ESCRT-III spirals and their relationship to HIV budding

    Anil G Cashikar et al.
    Electron microscopy on native membranes reveals the shape and potential function of protein machinery responsible for budding vesicles and viruses away from the cytoplasm.
    1. Neuroscience

    Semi-intact ex vivo approach to investigate spinal somatosensory circuits

    Junichi Hachisuka et al.
    A new spinal somatosensory preparation is described which enables fine control of sensory input and the ability to manipulate spinal interneurons while recording from spinal projection neurons.
    1. Neuroscience

    The human auditory brainstem response to running speech reveals a subcortical mechanism for selective attention

    Antonio Elia Forte et al.
    Selective attention to one of two speakers consistently modulates the response of the human auditory brainstem to each speaker's pitch.

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