12 results found
    1. Neuroscience

    Optogenetic strategies for high-efficiency all-optical interrogation using blue-light-sensitive opsins

    Angelo Forli et al.
    A new soma-targeted variant of the large-conductance blue-light-sensitive opsin CoChR combined with advanced optical stimulation methods allows high-efficiency all-optical neuronal imaging and stimulation in mouse brain in vivo.
    1. Neuroscience

    Sensitive red protein calcium indicators for imaging neural activity

    Hod Dana et al.
    Protein engineering and large-scale screening has led to the development of sensitive red fluorescent indicators that detect neural activity with high sensitivity in various animal models.
    1. Developmental Biology
    2. Neuroscience

    Transverse sinus injections drive robust whole-brain expression of transgenes

    Ali S Hamodi et al.
    A new viral injection method targets the transverse sinuses to achieve robust whole-brain delivery of single or multiple genes in multiple mammalian species early in development.
    1. Neuroscience

    Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency

    Richard B Crouse et al.
    The release of acetylcholine in the basolateral amygdala is precisely timed to salient events during reward learning but has long-lasting effects that potentiate learning of cue-reward contingencies.
    1. Neuroscience

    A multilayer circuit architecture for the generation of distinct locomotor behaviors in Drosophila

    Aref Arzan Zarin et al.
    Generation of a premotor/motor neuron comprehensive TEM reconstruction, functional optogenetics, and recurrent network modeling reveals different phase relationships among a subset of Drosophila motor neurons in forward versus backward locomotion.
    1. Neuroscience

    Functionally asymmetric motor neurons contribute to coordinating locomotion of Caenorhabditis elegans

    Oleg Tolstenkov et al.
    The 'missing' class of Caenorhabditis elegans excitatory motor neurons, AS, contribute to propagation and coordination of body waves, integrating information from, and feeding back to premotor interneurons byelectrical signaling.
    1. Neuroscience

    Characterization of developmental and molecular factors underlying release heterogeneity at Drosophila synapses

    Yulia Akbergenova et al.
    Active zone release probability is correlated with calcium channel density and calcium influx at single release sites, with release strength increasing in an activity-dependent manner during synapse maturation.
    1. Neuroscience

    The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle

    Carlos Manlio Díaz-García et al.
    When neurons are stimulated, calcium entry into mitochondria upregulates mitochondrial energy production, but glycolytic energy production in the cytosol is stimulated by elevated energy demand, not Ca2+ signaling.
    1. Neuroscience

    Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion

    Timothy W Dunn et al.
    Whole-brain activity imaging in larval zebrafish reveals brain regions that influence patterns of spontaneous movement to increase local exploration efficiency.
    1. Neuroscience

    Drosophila larval to pupal switch under nutrient stress requires IP3R/Ca2+ signalling in glutamatergic interneurons

    Siddharth Jayakumar et al.
    The transformation of fruit fly larvae into pupae provides insights into the processes that enable animals to survive periods of food shortage.

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