96 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Panton–Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS

    Bernadette C Young et al.
    Genome-wide association studies have established staphylococcal pyomyositis as a disease whose pathogenesis depends critically on expression of a single toxin, Panton–Valentine leukocidin.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

    Stefan Zdraljevic et al.
    Quantitative genetics approaches using Caenorhabditis elegans facilitate the discovery of a novel arsenic toxicity mechanism.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

    M Catarina Silva et al.
    A new Cereblon-recruiting bifunctional tau ligand, QC-01-175, promotes aberrant tau degradation and rescue of stress vulnerability in human neuronal cell models of tauopathy.
    1. Neuroscience

    Need-based prioritization of behavior

    C Joseph Burnett et al.
    A rich behavioral data set reveals the complex interactions and influence motivational systems have on one another, driving competition and optimal expression of behavior.
    1. Microbiology and Infectious Disease

    Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis

    Eva S Istvan et al.
    The malaria parasite Niemann-Pick Type C1-related protein is an important new antimalarial target.
  1. eLife Ambassadors: An invitation to take part in 2019

    The eLife Early-Career Advisory Group open applications for researchers who wish to join the second edition of the community advocacy programme.
  2. eLife Ambassadors: Reflections on a successful trial

    Early-career researchers involved in the pilot year of the new community scheme delivered results exceeding all expectations.
    1. Neuroscience

    Statistical structure of locomotion and its modulation by odors

    Liangyu Tao et al.
    A fly's locomotion can be decomposed into a small number of locomotor features which can be modulated by odors and other sensory information.
    1. Neuroscience

    The roles of vision and antennal mechanoreception in hawkmoth flight control

    Ajinkya Dahake et al.
    Mechanosensors in the antennae of hawkmoths provide rapid sensory feedback for the control of fast flight manoeuvres, which acts in parallel to visual information.
  3. Meeting Report: Changing the culture of scholarly communication

    eLife board member Dr. Prachee Avasthi led a lively evening debate in Cambridge, UK.

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