1,269 results found
    1. Cancer Biology
    2. Immunology and Inflammation

    Special Issue: Call for papers at the interface of Cancer Biology and Immunology

    eLife is pleased to announce ‘Discovery and Translation of Cancer Immunology: A Special Issue’, curating the very best research in this field.
  1. In Publishing: The latest on the open-source publishing platform Libero

    An update on the development of eLife’s publishing suite, what’s next, and how publishers, libraries and developers can get involved.
    1. Human Biology and Medicine
    2. Structural Biology and Molecular Biophysics

    A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

    Wenli Dai et al.
    TBX5-loss associated cardiomyocyte ectopy and atrial fibrillation is prevented by augmentation of SERCA2 activity, establishing a mechanism underlying the genetic basis for a Ca2+-dependent pathway for AF risk.
    1. Microbiology and Infectious Disease

    Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis

    Eva S Istvan et al.
    The malaria parasite Niemann-Pick Type C1-related protein is an important new antimalarial target.
  2. Izumi Fukunaga viewing the Okinawan cherry blossoms

    First Paper As PI: Izumi Fukunaga

    Time management can be a challenge for a new faculty member – but the science is rewarding.
  3. Plaudit logo

    From our Sprint to your browser: an update on Plaudit

    We present a new mechanism for the academic community to openly endorse publications.
  4. A series of articles on the philosophy of biology

    Philosophy of Biology

    Curated by Helga Groll
    A series of articles offering philosophical perspectives on the life sciences.
  5. Patricia Cabezas

    Interview: Diving into science management

    Patricia Cabezas explains how science management roles require many of the transferable skills developed during the PhD and postdoc.
  6. Philosophy of Biology: Philosophical bias is the one bias that science cannot avoid

    Fredrik Andersen et al.
    Scientists should be aware of the non-empirical assumptions that influence all kinds of research.
    1. Cancer Biology
    2. Cell Biology

    Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

    Qian Liu et al.
    The pro-apoptotic BH3-protein Bim contains two distinct binding sites for anti-apoptotic proteins that together confer resistance of Bim/Bcl-2 and Bim/Bcl-XL complexes to BH3-mimetic drugs under development for use in humans.

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