Shun-Hsiao Lee, Lissa Nicola Princz ... Christian Biertümpfel
The crystal structure of human Holliday junction resolvase GEN1 in complex with DNA reveals a conserved chromodomain as an additional DNA-anchoring point that opens new perspectives for enzyme regulation.
Thomas Esmangart de Bournonville, Mariusz K Jaglarz ... Roland Le Borgne
In response to disruption of barrier functions mediated by septate junctions, Drosophila epithelial cells restrict endosomal degradation of transmembrane cell adhesion proteins to promote their recycling in order to maintain tissue integrity.
The exon junction complex regulates the cell polarity determinant Discs large 1, which acts independently from its role in cell polarity to protect Dishevelled protein from lysosomal degradation in Wingless/Wnt signaling.
Helena Brezovjakova, Chris Tomlinson ... Vania MM Braga
Junction Mapper is a powerful new semi-automated software that provides a fingerprint of cell–cell contact morphometry and receptor density alterations.
William R Reay, Sahar I El Shair ... Murray J Cairns
Genetic data revealed existing drugs that could be repurposed to improve lung function, with evidence that compounds which control blood glucose could be particularly useful for respiratory impairment.
Subhendu Roy Choudhury, Anand K Singh ... Saverio Brogna
Deposition of the exon junction complex is thought to be the missing link between pre-mRNA splicing and translation in multicellular organisms, but no evidence of such deposition has been found in Drosophila.
Munenori Ishibashi, Joyce Keung ... Stephen C Massey
Each cone terminal is electrically coupled to around 50 nearby rods, forming a switchable circuit, known as the secondary rod pathway, in which all gap junction channels participate.
Ipsita Agarwal, Zachary L Fuller ... Molly Przeworski
Loss-of-function mutations in human genes are an important class of disease causing variation, and estimates of their effects on evolutionary fitness can be used to evaluate their pathogenicity.
Super-resolution imaging uncovers sparse occludin vs. clustered ZO1/claudin-5 architecture, and claudin-5 arrangement compacting during blood-brain-barrier tight-junction (TJ) maturation in which TJs become first restrictive to large and later to small molecules.
Characterization of Tnc as a selective integrin ligand at the Drosophila NMJ allows for unprecedented insights into our understanding of extracellular matrix/integrin interactions at synaptic locations and reveals novel, distinct presynaptic and postsynaptic integrin functions.
