258 results found
    1. Neuroscience

    Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry

    Michiel Vellema et al.
    The ability to quickly re-acquire a previously lost motor skill is associated with lasting synaptic changes in the brain circuit that controls that motor skill.
    1. Developmental Biology

    3D Imaging: Taking a closer look at whole organisms

    Noriko Ichino, Stephen C Ekker
    By enabling researchers to image whole zebrafish with cellular resolution, X-ray histotomography will improve our understanding of the biological differences between individuals of the same species.
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    1. Developmental Biology

    Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography

    Yifu Ding et al.
    X-ray histotomography produces the first 3-dimensional images with the combined submicron resolution, centimeter fields-of-view, soft-tissue contrast, and potential throughput to enable quantitative, histopathological and centimeter-scale phenotyping for whole-organism phenomics.
    1. Cell Biology

    Proinsulin misfolding is an early event in the progression to type 2 diabetes

    Anoop Arunagiri et al.
    Proinsulin misfolding, an established cause of diabetes in patients with INS gene mutations, is now observed in normal human pancreatic islets, and rodents with genetic predisposition to type 2 diabetes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Predominance of cis-regulatory changes in parallel expression divergence of sticklebacks

    Jukka-Pekka Verta, Felicity C Jones
    Cis-regulation such as enhancers and promoters plays a major role in parallel gene expression divergence and has features that make it a well-poised substrate for adaptive evolution.
    1. Evolutionary Biology

    A multidisciplinary approach to a unique palaeolithic human ichnological record from Italy (Bàsura Cave)

    Marco Romano et al.
    Traces of crawling locomotion, including children younger than 3 years old, are documented for the first time in the global human ichnological record.
    1. Cell Biology
    2. Evolutionary Biology

    Sterol transfer by atypical cholesterol-binding NPC2 proteins in coral-algal symbiosis

    Elizabeth Ann Hambleton et al.
    Diversification of a conserved cholesterol binder drives functional replacement of cholesterol with symbiont-produced sterols in corals living in nutrient-poor environments.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stem cell topography splits growth and homeostatic functions in the fish gill

    Julian Stolper et al.
    The fish gill, an ever-growing organ with fast turnover rate, displays dedicated stem-cell populations for growth and homeostasis that are interchangeable upon external challenges.
    1. Neuroscience

    Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

    Rui Gao et al.
    Polyglutamine expansion in mutant huntingtin disrupts a novel transcription-coupled DNA repair complex, providing an undescribed mechanism of neuronal toxicity and degeneration in Huntington's disease.
    1. Neuroscience

    Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts

    Mathan K Raja et al.
    Synaptophysins and gyrins dampen synaptic strength selectively at low frequencies, hinting that synaptic transmission may play a frequency filtering role in biological computation that is more general than currently envisioned.

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