258 results found
    1. Plant Biology
    2. Developmental Biology

    Sugar is an endogenous cue for juvenile-to-adult phase transition in plants

    Sha Yu et al.
    Sugar levels in leaves act as a signal for plants to switch from their juvenile to their adult form by regulating the expression of two genes.
    1. Cell Biology
    2. Neuroscience

    EFHC1, implicated in juvenile myoclonic epilepsy, functions at the cilium and synapse to modulate dopamine signaling

    Catrina M Loucks et al.
    C. elegans EFHC1 influences neuronal transmission through the cilium and the synapse.
    1. Neuroscience

    Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis

    Benedikt Grünewald et al.
    Impaired GABAergic and glutamatergic synaptic function and loss of interneurons in the amygdala, hippocampus, and cerebellum cause characteristic disease symptoms in a mouse model juvenile neuronal ceroid lipofuscinosis.
    1. Human Biology and Medicine

    Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

    John B Lees-Shepard et al.
    Daily palovarotene treatment reduces pathogenic expansion of fibro/adipogenic progenitors but results in long bone growth plate loss and overgrowths of synovial cartilage in juvenile mice.
    1. Neuroscience

    Neural activity in cortico-basal ganglia circuits of juvenile songbirds encodes performance during goal-directed learning

    Jennifer M Achiro et al.
    Activity in cortico-basal ganglia circuits of juvenile songbirds reflects evaluative signals necessary for comparing self-generated behavior to a goal representation during skill learning.
    1. Human Biology and Medicine

    Comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'

    Maurizio Pacifici, Eileen M Shore
    We are writing to communicate our concerns regarding the recently published study by Lees-Shepard et al. (2018).
    1. Human Biology and Medicine
    2. Stem Cells and Regenerative Medicine

    Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'

    David J Goldhamer, John B Lees-Shepard
    We respond to concerns expressed by Pacifici and Shore (2019) about our recent paper (Lees-Shepard et al., 2018a).
    1. Ecology

    Implications of being born late in the active season for growth, fattening, torpor use, winter survival and fecundity

    Britta Mahlert et al.
    Being born late in the active season is associated with a fast life history in a hibernating species, the garden dormouse (Eliomys quercinus).
    1. Neuroscience

    A subcortical circuit linking the cerebellum to the basal ganglia engaged in vocal learning

    Ludivine Pidoux et al.
    The cerebellum sends a functional input to the song-related basal ganglia via the thalamus in songbirds that can modify premotor activity, and it participates to song learning in juvenile birds.
    1. Developmental Biology
    2. Plant Biology

    Sugar promotes vegetative phase change in Arabidopsis thaliana by repressing the expression of MIR156A and MIR156C

    Li Yang et al.
    Sugar levels in leaves act as a signal for plants to switch from their juvenile to their adult form by regulating the expression of two genes.

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