10,782 results found
    1. Neuroscience

    Sub-second dynamics of theta-gamma coupling in hippocampal CA1

    Lu Zhang, John Lee ... Annabelle C Singer
    A combination of signal processing and machine learning form a new approach to classify oscillatory coupling in single cycles without averaging over time and to capture cycle-by-cycle changes in coupling.
    1. Neuroscience

    Male rats emit aversive 44-kHz ultrasonic vocalizations during prolonged Pavlovian fear conditioning

    Krzysztof Hubert Olszyński, Rafał Polowy ... Robert Kuba Filipkowski
    When exposed to prolonged stressful stimulation, rats start to emit long, frequency-unmodulated 44-kHz ultrasonic vocalizations, usually within the 35–50 kHz range, along with, previously described, long and unmodulated 22-kHz ultrasonic vocalizations.
    1. Cell Biology

    The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle

    Faye M Nixon, Cristina Gutiérrez-Caballero ... Stephen J Royle
    Microtubules of mitotic spindle fibers are positioned and held together by a meshwork of multipolar connectors.
    1. Computational and Systems Biology
    2. Neuroscience

    Characterizing functional pathways of the human olfactory system

    Guangyu Zhou, Gregory Lane ... Christina Zelano
    Human primary olfactory cortical regions can be parcellated into anatomically distinct areas based on whole-brain functional connectivity profiles, suggesting distinct, parallel functional pathways in the human olfactory system.
    1. Neuroscience

    A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans

    Laura D Lewis, Giovanni Piantoni ... Patrick L Purdon
    Intracranial recordings of human brain activity during awakening from general anesthesia exhibit a brief brain state not seen during loss of consciousness, in which stimuli elicit large electrophysiological responses that resemble those seen in sleep.
    1. Chromosomes and Gene Expression

    Bisulfite treatment and single-molecule real-time sequencing reveal D-loop length, position, and distribution

    Shanaya Shital Shah, Stella R Hartono ... Wolf-Dietrich Heyer
    D-loops are critical intermediates in homologous recombination, and the novel D-loop mapping assay defines position, length, and distribution of D-loops with near base-pair resolution.
    1. Genetics and Genomics

    Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans

    Lucydalila Cedillo, Fasih M Ahsan ... Alexander A Soukas
    Increased production of ether lipids is required to extend lifespan in response to metformin, phenformin, and multiple, distinct, longevity-promoting manipulations, illuminating the possibility that raising ether lipid levels represents a new therapeutic strategy to support healthy aging.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism

    Damon JA Frampton, Koushik Choudhury ... Sara I Liin
    Polyunsaturated fatty acids facilitate or impede Kv7 channel activation, depending on channel subtype and their dominant functional site(s).
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Quantitative control of noise in mammalian gene expression by dynamic histone regulation

    Deng Tan, Rui Chen ... Wei Huang
    Ubiquitous transcriptional factor-CBP/p300 interaction induces epigenetic and transcriptional bimodality, which can be utilized to tune mean gene expression and noise independently.
    1. Neuroscience

    BAD and KATP channels regulate neuron excitability and epileptiform activity

    Juan Ramón Martínez-François, María Carmen Fernández-Agüera ... Gary Yellen
    Altered activity of ATP-sensitive K+ channels underlies the metabolic seizure resistance produced by genetic manipulation of the BAD protein in mice.

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