29 results found
    1. Neuroscience

    Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress

    Abigail M Polter et al.
    Rats exposed to a single stressful event experience days-long constitutive activation of the kappa opioid receptor at inhibitory synapses in part of the brain’s reward system, which increases their drug-seeking behavior.
    1. Neuroscience

    Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice

    Lara S Hwa et al.
    Heavy alcohol drinking primes dynorphin /kappa opioid systems in the bed nucleus of the stria terminalis to alter stress responses in mice.
    1. Neuroscience

    Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds

    Shanna L Resendez et al.
    The neural mechanisms that underlie the maintenance of social bonds between prairie voles suggest that social support networks may be a powerful way of treating addiction.
    1. Biochemistry and Chemical Biology

    Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

    Rajendra Uprety et al.
    The structure-based design established a new approach to control pathway-selective activation of opioid receptors, resulting in new dual MOR/KOR G-protein biased agonist analgesics with attenuated liabilities.
    1. Cell Biology

    Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides

    Jennifer M Kunselman et al.
    Different dynorphins, which signal similarly from the cell surface, can differentially localize G protein-coupled receptors to specific subcellular compartments and cause divergent receptor fates and distinct spatiotemporal patterns of signaling.
    1. Neuroscience

    Different neuronal populations mediate inflammatory pain analgesia by exogenous and endogenous opioids

    Xin-Yan Zhang et al.
    Exogenous opioid analgesia is mediated by MORs expressed in glutamatergic neurons, whereas endogenous opioid analgesia is mediated by MORs expressed in GABAergic neurons.
    1. Biochemistry and Chemical Biology

    Structural and functional characterization of G protein–coupled receptors with deep mutational scanning

    Eric M Jones et al.
    Linking deep mutational scanning with engineered transcriptional reporters in human cell lines establishes a generalizable method for exploring pharmacogenomics, structure, and function across broad classes of drug receptors.
    1. Neuroscience

    Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron

    Xinhuai Liu et al.
    The arcuate nucleus kisspeptin neurons express multiple transmitters but use only the neuropeptide kisspeptin to drive the episodic secretion of gonadotropin-releasing hormone.
    1. Neuroscience

    Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

    Seksiri Arttamangkul et al.
    Opioid sensitive neurons were identified using a traceless affinity labeling strategy to covalently label endogenous mu-opioid receptors with fluorescent compounds in living brain slices from wild type animals.
    1. Neuroscience

    In vivo detection of optically-evoked opioid peptide release

    Ream Al-Hasani et al.
    In vivo detection of optically evoked endogenous opioid peptides reveals anatomically distinct release profiles.

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