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, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation
Li Pan et al.
Unbiased analyses highlight context-specific crosstalk between Notch, DNA damage response genes, and PP2A, and provide a roadmap for understanding how Notch induces squamous cell differentiation.
Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells
Pedro Lee et al.
Wounded epidermal keratinocytes emit a signal that activates a specialized T-cell in the skin, leading to an increase in hair follicle stem cell numbers that contributes to tissue repair.
The cellular basis of mechanosensory Merkel-cell innervation during development
Blair A Jenkins et al.
Touch-sensitive neurons are patterned during mammalian skin development by placode-derived keratinocytes and Bone Morphogenetic Protein signaling.
Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1
Yajuan Guo et al.
Keratin filaments are revealed as novel regulators of entry into terminal differentiation in the epidermis via an ability to modulate YAP1 function and Hippo signaling.
Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors
AJ Venkatakrishnan et al.
SARS-CoV-2 receptor ACE2 is expressed in nasal olfactory epithelia, tongue keratinocytes and small intestine enterocytes, connected with the COVID-19 patient phenotypes such as anosmia and diarrhea.
Type XVII collagen coordinates proliferation in the interfollicular epidermis
Mika Watanabe et al.
Type XVII collagen, a transmembranous protein in basal keratinocytes, suppresses interfollicular epidermal proliferation in neonatal and aged skin, and helps rejuvenate epidermis.
Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex
Nicole Ann Najor et al.
A protein interaction screen revealed desmosomes as a scaffold for the COP9 de-neddylating complex, to promote epidermal differentiation by governing the balance of Nedd8 and Ubiquitin modifications on Epidermal Growth Factor Receptor.
represses selection and expansion of oncogenic
transformed tumor initiating cells
Kent Riemondy et al.
mutations promotes skin cancer initiation.
Chromosomes and Gene Expression
Genetics and Genomics
Dissecting the DNA binding landscape and gene regulatory network of p63 and p53
Konstantin Riege et al.
A resource of p63-regulated genes, genomic loci bound by p63, p63 DNA recognition motifs, and potential co-factors is generated through a meta-analysis of high-throughput datasets.
Immunology and Inflammation
Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility
Sara Cipolat et al.
A mouse model of atopic dermatitis provides mechanistic evidence for an association between allergic disease and skin cancer.
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