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    1. Cancer Biology
    2. Cell Biology

    IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation

    Li Pan et al.
    Unbiased analyses highlight context-specific crosstalk between Notch, DNA damage response genes, and PP2A, and provide a roadmap for understanding how Notch induces squamous cell differentiation.
    1. Cell Biology
    2. Developmental Biology

    Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells

    Pedro Lee et al.
    Wounded epidermal keratinocytes emit a signal that activates a specialized T-cell in the skin, leading to an increase in hair follicle stem cell numbers that contributes to tissue repair.
    1. Developmental Biology
    2. Neuroscience

    The cellular basis of mechanosensory Merkel-cell innervation during development

    Blair A Jenkins et al.
    Touch-sensitive neurons are patterned during mammalian skin development by placode-derived keratinocytes and Bone Morphogenetic Protein signaling.
    1. Cell Biology

    Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1

    Yajuan Guo et al.
    Keratin filaments are revealed as novel regulators of entry into terminal differentiation in the epidermis via an ability to modulate YAP1 function and Hippo signaling.
    1. Medicine

    Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors

    AJ Venkatakrishnan et al.
    SARS-CoV-2 receptor ACE2 is expressed in nasal olfactory epithelia, tongue keratinocytes and small intestine enterocytes, connected with the COVID-19 patient phenotypes such as anosmia and diarrhea.
    1. Developmental Biology

    Type XVII collagen coordinates proliferation in the interfollicular epidermis

    Mika Watanabe et al.
    Type XVII collagen, a transmembranous protein in basal keratinocytes, suppresses interfollicular epidermal proliferation in neonatal and aged skin, and helps rejuvenate epidermis.
    1. Cell Biology

    Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex

    Nicole Ann Najor et al.
    A protein interaction screen revealed desmosomes as a scaffold for the COP9 de-neddylating complex, to promote epidermal differentiation by governing the balance of Nedd8 and Ubiquitin modifications on Epidermal Growth Factor Receptor.
    1. Developmental Biology
    2. Cancer Biology

    MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells

    Kent Riemondy et al.
    Inhibition of microRNA-203 by oncogenic HRas mutations promotes skin cancer initiation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dissecting the DNA binding landscape and gene regulatory network of p63 and p53

    Konstantin Riege et al.
    A resource of p63-regulated genes, genomic loci bound by p63, p63 DNA recognition motifs, and potential co-factors is generated through a meta-analysis of high-throughput datasets.
    1. Cell Biology
    2. Immunology and Inflammation

    Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility

    Sara Cipolat et al.
    A mouse model of atopic dermatitis provides mechanistic evidence for an association between allergic disease and skin cancer.