54 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Recurrent loss of HMGCS2 shows that ketogenesis is not essential for the evolution of large mammalian brains

    David Jebb, Michael Hiller
    The evolutionary loss of the main enzyme required for ketone body biosynthesis suggests that alternative strategies to provide energy for large brains during fasting evolved repeatedly in mammals.
    1. Immunology and Inflammation

    Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice

    Seungjin Ryu et al.
    Ketogenic diet protects against coronavirus-infected aged mice, which, like humans, are significantly more susceptible to infections, by deactivating NLRP3 inflammasome, reducing pathogenic monotypes, and expanding γδ T cells in the lung.
    1. Developmental Biology

    Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

    Man Chu et al.
    Analyses with genetically engineered mouse models in combination with biochemical approaches reveal a crucial role of the receptor tyrosine kinase Tie2 mediated signals in venogenesis via an Akt mediated regulation of COUP-TFII protein stabilization.
    1. Medicine

    Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics

    Julia Stokes et al.
    Volatile anesthetics impair hepatic tricarboxylic acid cycle function in adult and neonatal mice, with citrate accumulation driving a neonate-specific inhibition of beta-oxidation and ketosis through their increased relative sensitivity to malonyl-CoA.
    1. Biochemistry and Chemical Biology

    Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

    Vanja Panic et al.
    Mitochondrial pyruvate transport is required for brown fat thermogenesis.
    1. Developmental Biology

    Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signaling

    Yi Wang et al.
    Cells in tendon sheaths, considered to be extrinsic tissues of tendon, possess stem or progenitor cell properties that are involved in tendon repair by activating the Hh-TGFb/Smad3 axis.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development

    Jennifer Hampton Hill et al.
    A previously undescribed protein produced by certain resident intestinal bacteria induces zebrafish pancreatic beta cell expansion.
    1. Developmental Biology

    Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

    Gianpaolo Rando et al.
    Glucocorticoid receptor directly regulates the transcriptional activity of peroxisome proliferator-activated alpha (PPARα) before birth in anticipation of the sudden shifts in the postnatal nutrient source and metabolic demands.
    1. Ecology
    2. Neuroscience

    Dopamine drives Drosophila sechellia adaptation to its toxic host

    Sofía Lavista-Llanos et al.
    The insect dopaminergic system serves an important function in the regulation of ontogenesis and early development, contributing to the evolutionary processes that limit the ecological niche of Drosophila sechellia.
    1. Developmental Biology
    2. Plant Biology

    A digital 3D reference atlas reveals cellular growth patterns shaping the Arabidopsis ovule

    Athul Vijayan et al.
    Deep imaging, machine-learning-based segmentation, and tissue annotation resulted in a developmental series of 3D digital ovules with cellular resolution allowing next-level analysis of the ontogenesis of this complex organ.

Refine your results by:

Type
Research categories