Ryan G Natan, John J Briguglio ... Maria Neimark Geffen
Two distinct types of inhibitory neurons increase the brain's sensitivity to unexpected acoustic signals by amplifying selective suppression of cortical responses to frequent, but not rare sounds.
James E Gomez, Benjamin B Kaufmann-Malaga ... Deborah T Hung
Mutations in several components of a bacterial ribosome are shown to broadly decrease antibiotic and stress sensitivity, and readily accessible reversion mutations allow these ribosomal mutations to serve as stepping stones to high level antibiotic resistance.
Meredith A Sommars, Krithika Ramachandran ... Grant D Barish
B cell lymphoma 6 (BCL6) represses fasting gene expression by opposing peroxisome proliferator-activated receptor alpha (PPARa) activity at enhancers, and its ablation protects against steatosis by enhancing fatty acid catabolism.
Karla J Suchacki, Benjamin J Thomas ... William P Cawthorn
The health benefits of caloric restriction, including decreasing body fat and blood glucose, differ between males and females and this difference depends on the age at which caloric restriction begins.
AAV-Txnip prolongs vision in mouse models of blindness, enhancing lactate catabolism, mitochondrial health, and ATP production in a condition that likely has a limited glucose supply.
Experiments with realistic acoustic stimuli have revealed that humans distinguish salient sounds from background noise by integrating frequency and temporal information.
Mattia Aime, Elisabete Augusto ... Frederic Gambino
The frontal associative cortex promotes fear learning by non-linearly integrating Gaussian noise in between conditioning trials with the help of basolateral amygdala inputs.
Perceived imminence of threat and resulting intensity of defensive responses during serial compound stimulus conditioning are determined by auditory stimulus salience, not cue sequence as recently reported.
Everyday soundscapes dynamically engage attention towards target sounds or salient ambient events, with both attentional forms engaging the same fronto-parietal network but in a push-pull competition for limited neural resources.
