2,248 results found
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

    Lili Liao et al.
    Major secondary tumor suppressors in kidney cancer are required to maintain the activity of a tumor suppressive transcription factor after the loss of the primary tumor suppressor VHL.
    1. Cancer Biology
    2. Genetics and Genomics

    Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

    Jianing Xu et al.
    A distinct class of kidney tumors is characterized not by patterns of somatic mutations, but by a distinct metabolism.
    1. Cancer Biology
    2. Computational and Systems Biology

    5-hydroxymethylcytosine marks regions with reduced mutation frequency in human DNA

    Marketa Tomkova et al.
    Different types of epigenetic DNA modifications affect the likelihood of cytosine mutations in cancer.
    1. Cancer Biology

    Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition

    Andrew L Hong et al.
    Faithful models of RMC require SMARCB1 loss for survival, and genetic and small-molecule screens identify inhibition of the ubiquitin-proteasome system (UPS) as a potential therapeutic approach for SMARCB1 deficient cancers.
    1. Biochemistry and Chemical Biology

    Mechano-redox control of integrin de-adhesion

    Freda Passam et al.
    Ligand binding, force and chemistry combine to control the function of a cell surface receptor.
    1. Cancer Biology
    2. Medicine

    Diagnostic potential of tumor DNA from ovarian cyst fluid

    Yuxuan Wang et al.
    Mutations in the DNA of ovarian cyst fluid can inform the need for surgery and indicate the type of neoplastic lesion present.
    1. Developmental Biology

    Erythropoietin signaling regulates heme biosynthesis

    Jacky Chung et al.
    EPO/JAK2/PKA signaling cascade via AKAP10 relocalization to the outer mitochondrial membrane results in the phosphorylation of the terminal heme synthesis enzyme ferrochelatase, which contributes to heme production in red cells.
    1. Cancer Biology

    Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

    Simeon U Springer et al.
    The creation of a non-invasive assay for detecting urothelial cancer could have a profound impact on how we find and treat the disease.
    1. Cancer Biology

    Supervised mutational signatures for obesity and other tissue-specific etiological factors in cancer

    Bahman Afsari et al.
    A supervised methodology for mutational signatures outperforms the current standard unsupervised approach revealing new tissue-dependent mutational signatures among which some for obesity.
    1. Developmental Biology

    Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates

    Michael W Susman et al.
    Kif26b, a new component of the evolutionarily conserved Wnt5a-Ror signaling pathway, is controlled by regulated proteolysis and plays crucial roles in mediating vertebrate embryonic tissue morphogenesis.

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