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A non-genetic, cell cycle dependent mechanism of platinum resistance in lung adenocarcinoma
Alvaro Gonzalez Rajal et al.
Immunology and Inflammation
Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node
Shannon M Walsh et al.
Antigen-phosphorothioate DNA conjugation provides a vaccination strategy where stable barcodes facilitate the detection and quantification of antigen using single-cell RNA sequencing.
Immunology and Inflammation
T cell self-reactivity during thymic development dictates the timing of positive selection
Lydia K Lutes et al.
Developing T cells whose TCRs have relatively low reactivity experience very brief TCR signaling events, experience delayed positive selection, and retaina preselection gene expression signature as they mature.
Biochemistry and Chemical Biology
Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine
Qiang Liu et al.
Identifying and understanding that local anesthetic dyclonine targets TRPV3 channels will help to conceive therapeutic interventions.
EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice
Yuki Osawa et al.
EXOC1 contributes to the proper differentiation balance of spermatogonial stem cells and spermatocyte syncytia formation by regulating the morphology of male germ cells.
A calcineurin-mediated scaling mechanism that controls a K
-leak channel to regulate morphogen and growth factor transcription
Chao Yi et al.
Calcineurin regulates an electrophysiological mechanism that activates the transcription of specific developmental genes in a heirarchical manner to scale fish appendages.
presynaptic inhibition regulates the gain and kinetics of retinal output neurons
Jenna Nagy et al.
Elimination of GABA
receptors from the axon terminals of specific retinal bipolar cell types alters the sensitivity and kinetics of retinal output.
A robust method for particulate detection of a genetic tag for 3D electron microscopy
James Rae et al.
Development of a new system for gold particle detection of a genetic tag for electron microscopy.
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation
David W Sanders et al.
A high-throughput microscopy screen for drugs that modulate SARS-CoV-2 spike-mediated membrane fusion identifies an essential role for cholesterol in both virus entry and syncytia formation.
Asprosin-neutralizing antibodies as a treatment for metabolic syndrome
Ila Mishra et al.
Anti-asprosin monoclonal antibodies, a promising pharmacotherapy for the treatment of metabolic syndrome-associated hyperglycemia, obesity, and dyslipidemia.
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