Single-cell transcriptomics of the zebrafish ovary identifies both major and minor cell types and provides a valuable resource for researchers interested in reproductive biology, stem cell biology, and aquatic toxicology.
Connor J Thompson, Zhaoqian Su ... Daniel K Schwartz
A combined experimental and computational approach was developed to understand lateral interactions between membrane-bound proteins and used to quantify the contributions of specific and non-specific interactions to cadherin cis-binding kinetics.
Multiple trans-synaptic tracing methods reveal that there is no spatial segregation between flexor and extensor premotor interneurons in the lumbar spinal cord.
In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.
One hundred one high-quality drosophilid genomes are released, along with low-cost assembly workflows, as an open community resource for studying genetics, ecology, and evolution in this important model system.
David W Sanders, Chanelle C Jumper ... Clifford P Brangwynne
A high-throughput microscopy screen for drugs that modulate SARS-CoV-2 spike-mediated membrane fusion identifies an essential role for cholesterol in both virus entry and syncytia formation.
David Trombley McSwiggen, Anders S Hansen ... Xavier Darzacq
Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.
Ryszard Stefan Gomolka, Lauren M Hablitz ... Yuki Mori
Mice with aquaporin-4 channel deletion exhibit larger interstitial spaces, brain volume and water content, alongside reduced CSF space volume, which may increased resistance towards brain fluid efflux and suppress glymphatic flow.
Sunitha Rangaraju, Gregory M Solis ... Michael Petrascheck
A transcriptome-based metric for aging reveals a longevity mechanism that specifically prolongs the duration of young adulthood rather than slowing overall aging.