1,219 results found
    1. Developmental Biology

    Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development

    David AD Munro et al.
    Embryonic macrophages encourage early kidney development, interact with developing renal blood vessels, are enriched for mRNAs linked to vascular development, and promote endothelial cross-connections.
    1. Developmental Biology

    Prostaglandin signaling regulates nephron segment patterning of renal progenitors during zebrafish kidney development

    Shahram Jevin Poureetezadi et al.
    Prostaglandin synthesis and PGE2 receptor activity are essential for mediating segmentation of renal progenitors during pronephros formation in the zebrafish.
    1. Developmental Biology

    Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron

    Nils O Lindström et al.
    The patterning of the nephron is driven by a gradient in the activity of β-catenin and further defined by a network of BMP, PTEN and NOTCH signalling.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Nephron progenitor commitment is a stochastic process influenced by cell migration

    Kynan T Lawlor et al.
    Stochastic cell migration modulates exposure to signals that regulate commitment in the nephron progenitor niche.
    1. Developmental Biology

    Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration

    Kieran M Short et al.
    Analysing developing mouse kidneys demonstrates nephron formation does not significantly impact branching morphogenesis of the ureteric bud, suggesting this process is distinct from branching in organs like the mammary gland.
    1. Developmental Biology

    Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment

    Lori L O'Brien et al.
    Wnt11 maintains nephron progenitor niche integrity during kidney development through its modulation of cellular dynamics.
  1. Developing kidneys: an interview with Peter Hohenstein

    Originally from the Netherlands, Peter Hohenstein has been in Edinburgh since 2001 and now has his own group in The Roslin Institute, studying the link between normal kidney development and kidney disease. He is married and has a 4 year old daughter (and three cats), and he enjoys music, ‘mainly old stuff with lots of guitars’.
  2. Point of view: Motivating participation in open science by examining researcher incentives

    Sarah E Ali-Khan et al.
    A survey of researchers at the Montreal Neurological Institute and Hospital provides insights into the challenges and opportunities involved in adopting an open science policy across an entire patient-oriented academic institution.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Meiosis: Stopping chromosomes from breaking bad

    Rima Sandhu, G Valentin Börner
    The scaffolding that holds chromosome pairs together plays a key role in limiting the levels of double-strand breaks.
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    1. Stem Cells and Regenerative Medicine

    Organoids: Synthetic scaffolds help airway cells reach maturity

    Marko Z Nikolić, Emma L Rawlins
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