Inhibition of GOT2 drives growth inhibitory reductive stress that can be rescued by electron acceptors in vitro, whereas GOT2 inhibition in endogenous or transplanted tumor models is tolerated without consequence, highlighting the importance of context when studying tumor metabolism.
A GWAS meta-analysis for OPLL identified fourteen significant genomic loci and a subsequent Mendelian randomization study provided genetic evidence for a causal effect of obesity on the pathogenesis of OPLL, especially one of its subtypes, thoracic OPLL.
David J Ottenheimer, Madelyn M Hjort ... Garret D Stuber
Individual neurons in a surprising number of frontal cortical regions encode the value of reward-predicting olfactory cues across distinct stimulus sets and experimental sessions.
Ryszard Stefan Gomolka, Lauren M Hablitz ... Yuki Mori
Mice with aquaporin-4 channel deletion exhibit larger interstitial spaces, brain volume and water content, alongside reduced CSF space volume, which may increased resistance towards brain fluid efflux and suppress glymphatic flow.
CCDC113 is a key structural hub for sperm axoneme and head-tail coupling apparatus (HTCA) stability, with defects leading to male infertility through disruption of sperm flagellar and HTCA integrity.
Loss of YAP1/TAZ expression in the pancreatic endocrine compartment is not a passive consequence of endocrine specification, rather, Hippo pathway-mediated inhibition of YAP1/TAZ in endocrine progenitors is a prerequisite for endocrine specification and differentiation.
