Kidney organoids are a high-fidelity system for investigating basement membrane regulation in development and disease.

Three-dimensional imaging was used to identify structural and quantitative features of developing lymphatics in the kidneys of mice, humans and in a genetic mouse model of polycystic kidney disease.

Single-cell RNA-sequencing identifies the precise cellular and molecular events that occur along the sepsis timeline in the kidney, pointing to potential biomarkers and therapeutic targets.

scRNA-seq revealed the fish kidney is a dual-functional entity with functionalities of both primary and secondary lymphoid organs and highlighted the multifaced biology of kidney in ancient vertebrates.

Engineered mesenchymal stem cells (MSCs) could produce mutant β-galactosidase and trigger nitric oxide (NO) release when the NO prodrug is systemically administered, which can achieve NO release in a precise spatiotemporal manner and augment the therapeutic efficiency of MSCs.

High-resolution optical microscopy is used to reveal the organization of extracellular matrix proteins within the basement membrane of the blood filtration barrier in the kidney at the nanometer scale.

The absolute affinities of thousands of variant antibodies are measured in parallel using a combination of cell sorting and high-throughput DNA sequencing.

A novel strategy is presented for quantitatively measuring protein-DNA and protein-protein interactions that regulate transcription in living cells.

A combination of genetic and molecular assays revealed that transcription factor Tfcp2l1 provides the basis for cell patterning and physiologic coordination in kidney collecting ducts.

Genetic and functional studies reveal a previously unrecognized role for a transmembrane protein in glomerular filtration barrier function.