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    1. Chromosomes and Gene Expression

    Translational initiation in E. coli occurs at the correct sites genome-wide in the absence of mRNA-rRNA base-pairing

    Kazuki Saito et al.
    E. coli ribosomes incapable of base-pairing with the Shine-Dalgarno sequence are still selective for annotated start sites, indicating these sites are hard-wired for initiation by other mRNA features.
    1. Neuroscience

    Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies

    Efrén Álvarez-Salvado et al.
    A high-throughput behavioral paradigm and computational modeling are used to decompose olfactory navigation in walking Drosophila melanogaster into a set of quantitative relationships between sensory input and motor output.
    1. Neuroscience

    Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors

    William Olson et al.
    Single-nociceptor tracing reveals a novel somatotopic organization for the mammalian pain system, and physiological recordings and peripheral optogenetic behavior assays suggest that it is a possible mechanism underlying region-specific pain sensation.
    1. Cell Biology

    Cell cycle entry triggers a switch between two modes of Cdc42 activation during yeast polarization

    Kristen Witte et al.
    Optogenetic control of Cdc42 activation during polarization of budding yeast demonstrates a cell cycle regulated switch between two distinct modes of positive feedback.
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of the 90S small subunit pre-ribosome

    Qi Sun et al.
    The nearly complete architecture of the gigantic 90S precursor of small ribosomal subunit is determined by cryo-EM.
    1. Cell Biology
    2. Developmental Biology

    Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy

    Naonobu Fujita et al.
    Analyses of a developmentally regulated Drosophila myofiber remodeling program provide insight into induced autophagy required for T-tubule membrane reorganization, and uncover a conserved Rab2 role in autophagosome-lysosome fusion.
    1. Cell Biology
    2. Developmental Biology

    Wnt proteins can direct planar cell polarity in vertebrate ectoderm

    Chih-Wen Chu, Sergei Y Sokol
    Vertebrate early ectoderm displays planar polarity manifested by a fluorescent sensor and this polarity can be instructed by Wnt ligands.
    1. Stem Cells and Regenerative Medicine

    Distinct mechanisms underlie oral vs aboral regeneration in the cnidarian Hydractinia echinata

    Brian Bradshaw et al.
    Stem cell migration underlies head regeneration in the cnidarian (jellies and their kin) Hydractinia, but the regeneration of other body parts is based on the gradual transformation of one tissue type into another.
    1. Microbiology and Infectious Disease

    The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

    Stephen Patterson et al.
    Biological and pharmacokinetic studies indicate that the anti-tubercular drug, delamanid, could be repurposed for the treatment of visceral leishmaniasis.
    1. Neuroscience

    Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function

    Bo Zhao et al.
    Super-resolution microscopy reveals a highly organized compartment in the stereocilia of mechanosensory hair cells of the inner ear, which is critical for hair cell function and affected in disease.