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    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Protein kinase C coordinates histone H3 phosphorylation and acetylation

    Zoulfia Darieva et al.
    Chromatin structure is altered following DNA replication stress through the activity of protein kinase C signalling which leads to functionally coupled histone H3 phosphorylation and acetylation events.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

    Bernard Khor et al.
    A chemical biology approach has identified the kinase DYRK1A as a new regulator of the inflammatory response.
    1. Neuroscience

    Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors

    Gabriella R Sterne et al.
    Targeting Abelson kinase can be beneficial for treating disorders characterized by dysregulated Down Syndrome Cell Adhesion Molecule signaling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation

    F Donelson Smith et al.
    Structural analysis of an AKAP18-protein kinase A complex reveals that regions of intrinsic disorder impact the phosphorylation of preferred substrates.
    1. Structural Biology and Molecular Biophysics

    Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex

    Sulochanadevi Baskaran et al.
    The first three-dimensional structure of the PI3KC3 complex I, which is involved in autophagy, provides a framework for understanding the allosteric regulation of lipid kinase activity.
    1. Microbiology and Infectious Disease

    An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei

    Mathieu Cayla et al.
    A trypanosome DYRK kinase that exhibits fundamental differences to conventional DYRK family regulation links parasite quorum sensing, signal transduction and developmental gene expression.
    1. Cell Biology
    2. Neuroscience

    Ser/Thr kinase Trc controls neurite outgrowth in Drosophila by modulating microtubule-microtubule sliding

    Rosalind Norkett et al.
    Microtubule-microtubule sliding and neurite outgrowth in Drosophila is controlled by a Ser/Thr kinase Tricornered via phosphorylation of a 'mitotic' motor protein Pavarotti.
    1. Neuroscience

    Protein kinase C is a calcium sensor for presynaptic short-term plasticity

    Diasynou Fioravante et al.
    Genetic and electrophysiology experiments provide the first direct evidence that protein kinase C is a calcium-sensing protein in post-tetanic potentiation, a form of synaptic plasticity that supports short-term memory.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Sorting of a multi-subunit ubiquitin ligase complex in the endolysosome system

    Xi Yang et al.
    A single transmembrane E3 ligase complex can regulate protein ubiquitination at multiple organelles using interchangeable targeting subunits.
    1. Cell Biology

    Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis

    Lei Wang et al.
    Ciliogenesis is regulated by a certain group of centriolar satellite proteins, among which an E3 ligase is tethered by PCM1 to maintain the normal level of pro-ciliogenic protein on centrioles.