MARCH5 mediates a pathway driving MCL1 degradation in response to cellular stress, which sensitizes to BH3 mimetic drugs targeting BCLXL and provides a broadly effective therapeutic strategy for solid tumors.
CDPK4 is a pleiotropic regulator controlling initiation of DNA replication, mitotic spindle assembly and flagellar activation during the early stages of Plasmodium transmission.
Protein kinase A-driven increases in c-MYC protein expression and tumor cell proliferation can be blocked by eIF4A inhibitors, suggesting a potential new treatment option for patients with oncogenic PKA activation.
Moitrayee Bhattacharyya, Margaret M Stratton ... John Kuriyan
Closed-ring and open-spiral assembly of the multi-subunit neuronal kinase CaMKII suggest a mechanism for how active subunits shuttle between individual assemblies, propagating stimulatory signals.
Martin Larhammar, Sarah Huntwork-Rodriguez ... Trent A Watkins
Two seemingly distinct cellular stress response pathways that contribute to neurodegeneration after axonal insults are now revealed to be under the control of a single master regulator of the neuronal injury response, the kinase DLK.
Fission yeast loses its heterochromatin stability at mating-type locus under high temperature due to compromised binding between heterochromatin protein Swi6HP1 and Atf1.
Sabrina F Mansilla, Agustina P Bertolin ... Vanesa Gottifredi
A new tumor suppressor function of p21, needed at each undamaged duplication cycle, ensures the adequate execution of the DNA replication program thereby protecting the genome integrity.
TOR kinase guides the transition of plant stem cells from the dormant embryonic state to the active adult state by integrating light and metabolic signals.
The essential role of focal adhesion kinase in locally regulating insulin secretion and calcium responses in pancreatic beta cells is identified through the use of the pancreatic slice technique.
