795 results found
    1. Cell Biology
    2. Neuroscience

    Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104

    Jiaxing Li et al.
    Synaptic defects previously attributed to loss of kinesin function are found to be mediated by the Wnd/DLK axonal injury signaling pathway, which restrains the total levels of presynaptic proteins in response to their accumulation.
    1. Structural Biology and Molecular Biophysics

    Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors

    Stefano Pernigo et al.
    X-ray crystallography reveals how kinesin-1 recognises a novel class of cargo adaptor motifs in an isoform-specific manner.
    1. Cell Biology
    2. Plant Biology

    Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin

    Juan Tian et al.
    Kinesin-like calmodulin-binding protein integrates microtubules and F-actin to assemble the cytoskeletal configuration needed for trichome formation.
    1. Structural Biology and Molecular Biophysics

    Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

    Joseph Atherton et al.
    Cryo-electron microscopy reconstructions of two microtubule-bound transport kinesins at 7 Å resolution reveal how microtubule track binding stimulates ADP release, primes the active site for ATP binding and enables force generation.
    1. Developmental Biology
    2. Immunology and Inflammation

    Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus

    Federico Andrea Moretti et al.
    T cell progenitor homing into the thymus requires kindlin-3 to stabilize their adhesion to vascular integrin ligands when blood flow velocities and shear rates increase during development.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Rab6-regulated KIF1C kinesin motor domain contributes to Golgi organization

    Peter L Lee et al.
    Rab6A binds directly to both the C-terminus and the N-terminal motor domain of the kinesin KIF1C to regulate vesicle motility and Golgi organization.
    1. Developmental Biology
    2. Neuroscience

    MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport

    Stephen R Tymanskyj et al.
    An under-studied microtubule-associated protein is found to regulate axon growth and branching by modulating microtubule-based organelle transport through its dual interactions with microtubules and the conventional kinesin motor.
    1. Structural Biology and Molecular Biophysics

    High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation

    Zhiguo Shang et al.
    Microtubule attachment fundamentally modifies kinesin's behavior by triggering a ‘clamshell’ opening of the nucleotide cleft, subsequently reversed by ATP binding, that couples to cargo translocation.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Kinesin motility is driven by subdomain dynamics

    Wonmuk Hwang et al.
    The motor protein kinesin utilizes its fuel molecule by active and concerted motions of its subdomains, while it rapidly interacts with the microtubule track by forming a wet and dynamic interface.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Kinesin-4 KIF21B is a potent microtubule pausing factor

    Wilhelmina E van Riel et al.
    Kinesin-4 KIF21B combines a processive motor activity with two non-motor microtubule-binding domains and an autoregulatory region to induce pausing of microtubule plus ends.

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