649 results found
    1. Cell Biology
    2. Neuroscience

    Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104

    Jiaxing Li et al.
    Synaptic defects previously attributed to loss of kinesin function are found to be mediated by the Wnd/DLK axonal injury signaling pathway, which restrains the total levels of presynaptic proteins in response to their accumulation.
    1. Cell Biology
    2. Plant Biology

    Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin

    Juan Tian et al.
    Kinesin-like calmodulin-binding protein integrates microtubules and F-actin to assemble the cytoskeletal configuration needed for trichome formation.
    1. Biophysics and Structural Biology

    Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

    Joseph Atherton et al.
    Cryo-electron microscopy reconstructions of two microtubule-bound transport kinesins at 7 Å resolution reveal how microtubule track binding stimulates ADP release, primes the active site for ATP binding and enables force generation.
    1. Biochemistry
    2. Cell Biology

    The Rab6-regulated KIF1C kinesin motor domain contributes to Golgi organization

    Peter L Lee et al.
    Rab6A binds directly to both the C-terminus and the N-terminal motor domain of the kinesin KIF1C to regulate vesicle motility and Golgi organization.
    1. Biophysics and Structural Biology

    High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation

    Zhiguo Shang et al.
    Microtubule attachment fundamentally modifies kinesin's behavior by triggering a ‘clamshell’ opening of the nucleotide cleft, subsequently reversed by ATP binding, that couples to cargo translocation.
    1. Biophysics and Structural Biology
    2. Computational and Systems Biology

    Kinesin motility is driven by subdomain dynamics

    Wonmuk Hwang et al.
    The motor protein kinesin utilizes its fuel molecule by active and concerted motions of its subdomains, while it rapidly interacts with the microtubule track by forming a wet and dynamic interface.
    1. Biophysics and Structural Biology
    2. Cell Biology

    Kinesin-4 KIF21B is a potent microtubule pausing factor

    Wilhelmina E van Riel et al.
    Kinesin-4 KIF21B combines a processive motor activity with two non-motor microtubule-binding domains and an autoregulatory region to induce pausing of microtubule plus ends.
    1. Biophysics and Structural Biology

    Structural basis of cooperativity in kinesin revealed by 3D reconstruction of a two-head-bound state on microtubules

    Daifei Liu et al.
    A novel algorithm is used to solve the first 3D reconstruction of a stepping kinesin dimer on microtubules, directly visualizing the conformational effects of inter-head strain and giving novel insights into the motility mechanism.
    1. Biophysics and Structural Biology
    2. Cell Biology

    Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers

    Jessica E Scholey et al.
    The Bipolar Assembly domain of kinesin-5 comprises an anti-parallel four-helix bundle, which explains how kinesin-5 subunits assemble into bipolar tetramers with two motile ends that transmit forces while crosslinking and sliding adjacent microtubules during mitosis.
    1. Biophysics and Structural Biology
    2. Cell Biology

    Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3

    Christine Mieck et al.
    The kinesin-14 motor Kar3 moves along microtubules using a previously undescribed mechanism that critically requires the presence of a non-catalytic head.

Refine your results by:

Type
Research categories