Theoretical study shows how enzymes can achieve substrate proofreading by taking advantage of existing molecular gradients in the cell while not being endowed with structural features typically required for proofreading.
Purified Pannexin 1 channels activated by caspase cleavage in proteoliposomes reconstitute a permeation pathway for intercellular signaling molecules important in inflammation and cell clearance.
Rejuvenation of corneal epithelium in homeostasis is determined by the interplay between corneal cells replicative lifespan and the spatial correlation between cell replication and cell removal.
The LINC complex has a core 6:6 structure in which KASH-binding induces head-to-head interactions between SUN trimers, suggesting force transduction between cytoskeletal and nuclear components through branched LINC complex networks.
Time-resolved and site-directed in vivo photo-crosslinking analysis of VemP allows identification of both cis- and trans-elements required for its regulated arrest-cancelation.
Structural and biochemical data suggest a mechanism for the Synaptojanin1-catalysed reaction and the role of mutations in the onset of associated neurological diseases.
When two signals increase transcription of the same gene, their combined effect tends to reflect either the sum of the individual increases or the product of the individual fold-changes.
Diverse muscle spindle firing, critical for a range of sensorimotor behaviors, is compactly explained by first principles of force development in specialized muscle fibers within the sensors.
Adhesion force measurements reveal that proper N-glycosylation of flagellar membrane proteins is crucial for adhering C. reinhardtii cells onto surfaces.
