PAR-6 and PKC-3/aPKC are essential for postembryonic development of C. elegans and control the organization of non-centrosomal microtubule bundles in the epidermis, likely through recruitment of NOCA-1/Ninein.
Using a proximity-dependent labeling approach in living cells, the human cytoplasmic dynein-1 interactome was identified and a new family of dynein activators, ninein and ninein-like, was discovered.
Live quantitative monitoring of transcriptional bursting reveals that enhancers responding to different regulators use the same kinetic strategy to produce a complex composite pattern of developmental expression.
Elucidating the control and regulation of acetate overflow in E. coli reveals that acetate is not only an end-product but also a co-substrate and a global regulator of glucose metabolism.
After developing a force-gliding assay with nanometer and piconewton precision, it is concluded that multiple kinesins driving a single cargo induces tension, resulting in smooth cargo transport, even with roadblocks.
The person-specific adjusted HbA1c addresses non-glycaemic variation in laboratory HbA1c due to red blood cell lifespan differences, potentially providing a better marker to predict diabetes complications and guide glycaemic management.
The tubulin GTPase cycle structurally modulates the microtubule cap, causing lattice expansion, which is an intermediate state involved in phosphate release and regulatory signaling.
A novel algorithm is used to solve the first 3D reconstruction of a stepping kinesin dimer on microtubules, directly visualizing the conformational effects of inter-head strain and giving novel insights into the motility mechanism.
