5,610 results found
    1. Computational and Systems Biology
    2. Neuroscience

    A kinematic synergy for terrestrial locomotion shared by mammals and birds

    Giovanna Catavitello et al.
    General principles of the limb segment control for terrestrial locomotion have emerged in evolution and highlight the existence of the laws of biological motion that apply to various animal species.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mapping transiently formed and sparsely populated conformations on a complex energy landscape

    Yong Wang et al.
    Molecular simulations can capture key aspects of the conformational exchange in a protein.
    1. Structural Biology and Molecular Biophysics

    High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation

    Zhiguo Shang et al.
    Microtubule attachment fundamentally modifies kinesin's behavior by triggering a ‘clamshell’ opening of the nucleotide cleft, subsequently reversed by ATP binding, that couples to cargo translocation.
    1. Neuroscience

    Energy exchanges at contact events guide sensorimotor integration

    Ali Farshchian et al.
    The brain obtains and preserves a consistent temporal alignment of multisensory and motor information flowing along staggered streams by maintaining an invariant estimate across modalities of the energy exchanged with the environment at discrete events.
    1. Structural Biology and Molecular Biophysics

    Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

    Joseph Atherton et al.
    Cryo-electron microscopy reconstructions of two microtubule-bound transport kinesins at 7 Å resolution reveal how microtubule track binding stimulates ADP release, primes the active site for ATP binding and enables force generation.
    1. Neuroscience

    Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling

    Naomi AK Hanemaaijer et al.
    High-speed calcium imaging from the axon initial segment shows that sodium channels are in part permeable to calcium ions.
    1. Neuroscience

    A synergy-based hand control is encoded in human motor cortical areas

    Andrea Leo et al.
    The human brain encodes coordinated patterns of joint movements – synergies – to increase the efficiency with which it can control complex hand movements.
    1. Cell Biology

    An essential and NSF independent role for α-SNAP in store-operated calcium entry

    Yong Miao et al.
    α-SNAP mediated rearrangement of Stim1 and Orai1 molecules within CRAC channel clusters is required for store-operated calcium entry.
    1. Genetics and Genomics

    Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity

    Arpan C Ghosh et al.
    A muscle-derived signaling molecule suppresses excessive accumulation of lipids in the Drosophila adipose tissue by activating the Pi3K/Akt/mTOR signaling cascade in the Drosophila hepatocyte-like cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1

    Fahad Rashid et al.
    Structure specific nucleases that act in DNA replication, repair and recombination actively mold their DNA while transforming their own structure to achieve precise cleavage of their cognate DNA and avoid the deleterious cleavage of noncognate DNA.

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