The West Nile Virus envelope protein catalyzes membrane fusion through low-pH induced conformational rearrangement, with a rate determined by the formation of two trimeric complexes at the contact zone between the virus and target membrane.

Elucidating the control and regulation of acetate overflow in E. coli reveals that acetate is not only an end-product but also a co-substrate and a global regulator of glucose metabolism.

The use of adequate statistics is demonstrated to be an essential prerequisite to derive conclusions on thermodynamics and kinetics from molecular simulations.

Collision between ribosomes can cause dissociation of stalled ribosomes from messenger RNAs during the process of mRNA translation.

The physical interaction network encoded in the multi-domain protein native structure handles the trade-off between the fast, stable folding and the efficient, reliable function.

A combination of glutamate imaging, multicompartmental modeling, and machine learning elucidates the peak theoretical and actual contributions of heterogeneous kinetics of presynaptic inputs to the computation of directional selectivity in retinal starburst amacrine cells.

The time it takes to secrete a protein is dominated by diffusion of positively charged arginines through the channel across the membrane, but lysines avoid this problem as they are neutralised before transport.

An entropy switch controls the Aurora B autoactivation process through two distinct kinetic steps of phosphorylation.

Molecular simulations can capture key aspects of the conformational exchange in a protein.

Coarse-grained modeling reveals a new mechanism for multispanning membrane protein topogenesis, in which misintegrated configurations of the proteins undergo post-translational annealing to reach final, fully integrated multispanning topologies.