5,877 results found
    1. Neuroscience

    Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo

    Taisuke Miyazaki et al.
    Excitatory and inhibitory postsynaptic receptors are maintained at corresponded postsynaptic sites with the different dependency of presynaptic neurons in the mature mammalian brain.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    circFL-seq reveals full-length circular RNAs with rolling circular reverse transcription and nanopore sequencing

    Zelin Liu et al.
    Accurate identification and quantification of various circRNA isoforms.
    1. Cell Biology
    2. Developmental Biology

    Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration

    Maureen C Lamb et al.
    Collectively migrating cells control their stiffness by Fascin-dependent control of Myosin activity, and this migratory cell stiffness regulates Myosin activity and stiffness within the cellular substrate to ultimately promote migration.
    1. Neuroscience

    NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load

    Theresa Pohlkamp et al.
    Genetic disruption of sodium-hydrogen exchanger 6 (NHE6) reduces amyloid plaques in humanized Alzheimer's disease mouse models and restores normal synaptic responses to neuromodulatory input in humanized ApoE4-expressing animals.
    1. Plant Biology

    A novel bivalent chromatin associates with rapid induction of camalexin biosynthesis genes in response to a pathogen signal in Arabidopsis

    Kangmei Zhao et al.
    A previously uncharacterized type of bivalent chromatin plays an important role controlling the timely induction of genes involved in making a potent defense metabolite upon a pathogen signal in Arabidopsis.
    1. Biochemistry and Chemical Biology

    Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

    Maria Carmela Filomena et al.
    Ablation of the sarcomeric protein myopalladin (MYPN), associated with human cardiomyopathies, results in dilated cardiomyopathy, which is severely aggravated by biomechanical stress, suggesting that skeletal myopathy patients carrying MYPN loss-of-function mutations may develop cardiomyopathy under conditions of cardiac stress.
    1. Ecology

    Echolocating toothed whales use ultra-fast echo-kinetic responses to track evasive prey

    Heather Vance et al.
    Echolocating toothed whales can detect and react to sudden prey movements during close approaches with speeds similar to ultra-fast tracking responses in human vision.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Virophages and retrotransposons colonize the genomes of a heterotrophic flagellate

    Thomas Hackl et al.
    Mutualistic viruses called virophages are common genome inhabitants of a marine protist, where they may protect host populations from giant viruses.

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