In Escherichia coli structural maintenance of chromosomes (SMC) complex, MukBEF, a dimeric MukF kleisin binds and activates MukB SMC ATPases through two independent interfaces provided by distinct MukF N- and C-terminal domains.
Single cell RNA sequencing reveals that mouse embryonic stem cells can be differentiated into the same terminal motor neuron state via distinct differentiation paths, one of which includes a surprising intermediate state not found in embryos.
A multi-scale integration of experimental and computational approaches shows how a non-linear dependence of T-type calcium channel gating on GABAB receptor activity regulates thalamic network oscillations.
Mechanisms that tether and release replicated sister chromatids to produce sperm and eggs rely extensively on meiotic cohesin complexes that are endowed with unexpectedly different properties specified by a single interchangeable subunit, the α-kleisin.
MRGPRD and MRGRPX1 are co-expressed in primate DRG neurons, but β-alanine and BAM8-22, preferentially activate CMH-subclasses, and co-activating different cutaneous nociceptors by pruritogens does not change itch sensation to pain.
Hinokiflavone is identified as a splicing modulator that blocks progression from spliceosome complex A to complex B and inhibits SUMO protease SENP1, causing hyper-SUMOylation affecting 6 U2 snRNP proteins.
Crawling Drosophila larvae and C. elegans exhibit diffusive behavior alongside directed motion, and the dynamics of this navigation can be analyzed with techniques developed in understanding protein folding, using a Markov state model.