870 results found
    1. Chromosomes and Gene Expression

    MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin

    Katarzyna Zawadzka, Pawel Zawadzki ... Lidia K Arciszewska
    In Escherichia coli structural maintenance of chromosomes (SMC) complex, MukBEF, a dimeric MukF kleisin binds and activates MukB SMC ATPases through two independent interfaces provided by distinct MukF N- and C-terminal domains.
    1. Neuroscience
    2. Physics of Living Systems

    Mechanical vibration patterns elicit behavioral transitions and habituation in crawling Drosophila larvae

    Alexander Berne, Tom Zhang ... Mason Klein
    Habituation to mechanical vibration of crawling Drosophila larvae exhibits distinct time constants that characterize desensitization, re-sensitization, and further adaptation to repeated stimulus patterns.
    1. Neuroscience
    2. Physics of Living Systems

    Continuous, long-term crawling behavior characterized by a robotic transport system

    James Yu, Stephanie Dancausse ... Mason Klein
    Drosophila larvae manipulated by an automated system can be observed for 30+ hr, and new analysis methods of long-timescale trajectories reveal behavioral features previously inaccessible, such as a bimodal distribution of thermal navigation efficiency in individual animals.
    1. Neuroscience

    Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice

    Yu Takagi, Laurence Tudor Hunt ... Miriam C Klein-Flügge
    Adaptation along multiple task-axes reveals choice traces at millisecond resolution in non-invasive recordings from human premotor cortex and provides evidence that theories of top-down control hold even after extensive experience.
    1. Neuroscience

    The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila

    Lina Ni, Mason Klein ... Paul A Garrity
    Two members of a widely studied family of chemoreceptors, the "orphan" chemoreceptor IR21a and its putative co-receptor IR25a, act together to mediate cool sensation in fruit fly larvae.
    1. Ecology
    2. Plant Biology

    A dynamic rhizosphere interplay between tree roots and soil bacteria under drought stress

    Yaara Oppenheimer-Shaanan, Gilad Jakoby ... Tamir Klein
    Increased root exudation rate under combined drought and bacterial inoculation and bacterial growth stimulation by specific exudation metabolites support the idea of root recruitment of beneficial bacteria, especially under water stress.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes

    Aaron F Severson, Barbara J Meyer
    Mechanisms that tether and release replicated sister chromatids to produce sperm and eggs rely extensively on meiotic cohesin complexes that are endowed with unexpectedly different properties specified by a single interchangeable subunit, the α-kleisin.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

    Maikel Castellano-Pozo, Georgios Sioutas ... Enrique Martinez-Perez
    Meiosis-specific cohesin complexes differing in their kleisin subunit display different chromosome binding dynamics and perform specialised functions in sister chromatid cohesion, chromosome axis organisation, and double-strand break repair.
    1. Chromosomes and Gene Expression

    Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit

    Shoji Tane, Keishi Shintomi ... Tatsuya Hirano
    In vitro assays using Xenopus egg extracts provide evidence that mitosis-specific loading of condensin I is accelerated by phosphorylation of the N-terminal tail of its kleisin subunit.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface

    Martin Houlard, Erin E Cutts ... Kim Nasmyth
    Chromosome condensation by condensin II is inhibited during interphase by direct interaction with MCPH1, which regulates opening of the condensin II interface between SMC2 and NCAPH2, in a similar fashion to how WAPL regulates Cohesin.

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