GPR88 inhibits G-protein signaling of nearby GPCRs, and dampens b-arrestin recruitment by all GPCRs tested, likely by sequestration in intracellular compartments.

A versatile invertible gene trap vector is generated and inserted into a defined genomic locus in zebrafish via homologous recombination, demonstrating an efficient genetic approach to performing conditional knockout analysis.

In red blood cells, the Piezo1 protein is responsible for sensing mechanical forces and volume regulation.

The untimely loss of the transcriptional repressor REST from dividing neural progenitors during embryogenesis leads to compromised genomic integrity.

Zfp106 functions as an RNA binding protein, binds directly to GGGGCC RNA repeats, is required in motor neurons to prevent ALS-like neurodegeneration in mice, and can suppress neurotoxicity in an established fly model of ALS.

An multi-species approach can be used to identify small molecules with properties that might prove useful for the treatment of some neuromuscular diseases.