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Mice with a mutation that disrupts the release of growth hormone show greatly increased lifespan, which can be further increased by caloric restriction.

The unfolded protein response sensor/transducer IRE1-mediated splicing of XBP1 mRNA encoding its active downstream transcription factor to maintain the homeostasis of the endoplasmic reticulum is sufficient for growth and development of medaka fish.

The double-gene-knockout pig is a valuable model to help understand the mechanisms of CD163 and pAPN in the infection of multiple viruses and offers excellent breeding materials for disease-resistant pigs.

GPR88 inhibits G-protein signaling of nearby GPCRs, and dampens b-arrestin recruitment by all GPCRs tested, likely by sequestration in intracellular compartments.

TBX5-loss associated cardiomyocyte ectopy and atrial fibrillation is prevented by augmentation of SERCA2 activity, establishing a mechanism underlying the genetic basis for a Ca²⁺-dependent pathway for AF risk.

The activity levels of two closely related MAPKKK are differentially regulated in Purkinje neuron survival.

Biochemical and cellular analyses reveal the mechanism by which EROS regulates NOX2 and P2X7 abundance in mouse and human.

Cell division by meiosis during sperm production depends on expression of an RNA-binding protein that prevents abnormal RNA-processing pathways.

Learning capacity depends on a dynamic interplay between the brain’s ability to change the strength of its synapses and the history of activity at those synapses.