244 results found
    1. Cell Biology
    2. Neuroscience

    A genetic toolkit for tagging intronic MiMIC containing genes

    Sonal Nagarkar-Jaiswal et al.
    Building on previous work (Nagarkar-Jaiswal et al., 2015), we report an elegant genetic strategy for endogenous tagging of MiMIC containing genes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Fusion surface structure, function, and dynamics of gamete fusogen HAP2

    Juan Feng et al.
    Structure, dynamics, and mutation of a gamete fusion protein and comparisons to viral homologues suggest that after trimerization the domain bearing the membrane-inserting fusion loops can pivot with respect to the trimer 3-fold axis.
    1. Neuroscience

    Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity

    Eiko Iwakoshi-Ukena et al.
    Neurosecretory protein GL, a previously unknown mammalian neuropeptide, is a novel hypothalamic factor which regulates feeding behavior and peripheral lipogenesis in animals.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

    Jixin Cui et al.
    Fam20A, a pseudokinase involved in the formation of tooth enamel, binds ATP in an unexpected orientation.
    1. Neuroscience

    Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis

    Mahdokht Kohansal-Nodehi et al.
    Global phosphoproteomic analysis in nerve terminal during exocytosis reveals 252 uniquely regulated phosphosites, highlighting complex regulation of active zone proteins at multiple sites and the role of specific kinases/phosphatases.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II

    Moitrayee Bhattacharyya et al.
    Closed-ring and open-spiral assembly of the multi-subunit neuronal kinase CaMKII suggest a mechanism for how active subunits shuttle between individual assemblies, propagating stimulatory signals.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin

    Haiyang Liu et al.
    The tail domain of Myosin III binds to and cross-links actin bundling protein Espin1 and thus modulates higher order actin bundle structures in cellular processes such as stereocilia and microvilli.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading

    Dongqing Pan et al.
    The stoichiometry and mechanism of interactions of the Mis18 complex with M18BP1 was analysed to unveil the molecular basis of new CENP-A deposition during the G1 phase of the cell cycle.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins

    Aimin Yang et al.
    Legionella effector RavZ evades host autophagy by extracting LC3-PE from the membrane before deconjugation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

    Carmela Sidrauski et al.
    A drug-like molecule called ISRIB, which activates the translation initiation factor eIF2B, antagonizes stress responses as diverse as protein misfolding and nutrient deprivation, and restores protein synthesis, enhancing memory.

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