7,346 results found
    1. Medicine

    Inference from longitudinal laboratory tests characterizes temporal evolution of COVID-19-associated coagulopathy (CAC)

    Colin Pawlowski, Tyler Wagner ... Venky Soundararajan
    Longitudinal laboratory testing results tied to SARS-CoV-2 diagnostic PCR results of more than 2500 patients reveal the temporal evolution of COVID-associated coagulopathy.
    1. Evolutionary Biology

    Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations

    Milo S Johnson, Shreyas Gopalakrishnan ... Michael M Desai
    Experimentally evolved yeast populations increase in fitness predictably but do not divide into coexisting lineages or dramatically increase their mutation rates after 10,000 generations.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Artificial selection methods from evolutionary computing show promise for directed evolution of microbes

    Alexander Lalejini, Emily Dolson ... Luis Zaman
    Multiobjective artificial selection methods from evolutionary computing show promise for improving directed evolution outcomes when selecting for multiple traits of interest.
    1. Computational and Systems Biology

    Calibration and analysis of genome-based models for microbial ecology

    Stilianos Louca, Michael Doebeli
    A novel computation tool for microbial community modeling predicts the evolution and diversification of E. coli in laboratory evolution experiments and gives insight into the underlying metabolic processes.
    1. Microbiology and Infectious Disease

    Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse

    Jingtao Lilue, Urs Benedikt Müller ... Jonathan C Howard
    Mechanisms that enable wild mice to survive infection with strains of the Toxoplasma gondii parasite virulent enough to kill laboratory mice offer an explanation for how these parasites have been able to persist in the mouse population.
    1. Evolutionary Biology

    Synthetic Biology: Shining a light on Ohno’s dilemma

    Isabella Tomanek
    Laboratory experiments on a fluorescent protein in E. coli reveal how duplicate genes are rapidly inactivated by mutations during evolution.
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    1. Developmental Biology
    2. Neuroscience
    Pond snail illustration

    The Natural History of Model Organisms: The unlimited potential of the great pond snail, Lymnaea stagnalis

    István Fodor, Ahmed AA Hussein ... Zsolt Pirger
    The great pond snail is a multipurpose model organism and a contemporary choice for addressing a wide range of biological questions, problems and phenomena in the laboratory and the field.
    1. Evolutionary Biology

    Mutational robustness changes during long-term adaptation in laboratory budding yeast populations

    Milo S Johnson, Michael M Desai
    Yeast populations lose mutational robustness during evolution in one environment but not in another due to the collective effect of a large number of idiosyncratic epistatic interactions.
    1. Microbiology and Infectious Disease

    Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant

    Dallas L Mould, Mirjana Stevanovic ... Deborah A Hogan
    Microbial variants that arise during chronic lung infections have an increased ability to use nutrients that are abundant in lung infections.
    1. Evolutionary Biology
    2. Neuroscience

    Linking the evolution of two prefrontal brain regions to social and foraging challenges in primates

    Sebastien Bouret, Emmanuel Paradis ... Cecile Garcia
    Across primates, volumes of specific brain regions relate to specific socio-ecological factors, bridging the gap between neuro-cognitive operations from laboratory studies and challenges primates face in their natural environment.

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