190 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Modes of flagellar assembly in Chlamydomonas reinhardtii and Trypanosoma brucei

    Johanna L Höög et al.
    Comparative electron tomography of growing flagellar tips reveals that axonemal growth differs between short and long flagella, and between species.
    1. Cancer Biology

    Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

    Caroline Contat et al.
    In lung adenocarcinoma, deleting one glucose transporter, whether it is Glut1 or Glut3 is insufficient, whereas their dual deletion reduces tumor growth.
    1. Microbiology and Infectious Disease

    The flagellar motor of Vibrio alginolyticus undergoes major structural remodeling during rotational switching

    Brittany L Carroll et al.
    In situ structures of the flagellar motors genetically docked in CCW and CW rotational states reveal major rearrangement that facilitates rotational switch in Vibrio alginolyticus..
    1. Cell Biology
    2. Physics of Living Systems

    Flagellar energetics from high-resolution imaging of beating patterns in tethered mouse sperm

    Ashwin Nandagiri et al.
    Calculations of flagellar energetics from beating patterns in sperm reveal that internal dissipation by dynein motors and other passive structures within the flagellum significantly exceeds external hydrodynamic dissipation.
    1. Cell Biology

    IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium

    Jenna L Wingfield et al.
    Multimegadalton intraflagellar transport (IFT) trains assemble by sequential recruitment of IFT subcomplexes from the cell body to the ciliary basal bodies and tubulin, the main IFT cargo, is loaded briefly before trains depart.
    1. Developmental Biology

    Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures

    Konstantinos Gkatzis et al.
    A serum-free organotypic culture model of mouse lung epithelial progenitors was developed and used to screen WNT modulators for regulators of epithelial differentiation.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Dynamics of the IFT machinery at the ciliary tip

    Alexander Chien et al.
    During intraflagellar transport (IFT), kinesin-II dissociates from IFT trains at the flagellar tip and its diffusion in flagella serves as a negative feedback mechanism that facilitates flagellar length control in Chlamydomonas.
    1. Stem Cells and Regenerative Medicine

    In vitro generation of human pluripotent stem cell derived lung organoids

    Briana R Dye et al.
    Directed differentiation of stem cells can generate ventral-anterior foregut spheroids that can expand into three-dimensional lung organoids with striking structural, cellular and molecular similarities to the human fetal lung.
    1. Genetics and Genomics
    2. Medicine

    Tendon and motor phenotypes in the Crtap-/- mouse model of recessive osteogenesis imperfecta

    Matthew William Grol et al.
    Ultrastructural, biochemical, and behavioral assessments reveal that the Crtap-/- mouse model of severe, recessive Osteogenesis Imperfecta presents with defects in tendon structure and strength that correlate with severe motor deficits.
    1. Cell Biology
    2. Evolutionary Biology

    Evolution of an ancient protein function involved in organized multicellularity in animals

    Douglas P Anderson et al.
    Experimentally reconstructing the evolution of the molecular complex that animals use to orient the mitotic spindle establishes a simple genetic and physical mechanism for the emergence of a function essential for multicellularity.

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