Browse the search results

Page 2 of 304
    1. Physics of Living Systems

    Mesoscale phase separation of chromatin in the nucleus

    Gaurav Bajpai, Daria Amiad Pavlov ... Samuel Safran
    Computer simulations show transitions between novel types of chromatin organization (peripheral, central, conventional) depending on chromatin interactions with itself, the lamin and nuclear hydration, measured in recent experiments.
    1. Neuroscience

    Dissociable laminar profiles of concurrent bottom-up and top-down modulation in the human visual cortex

    Samuel JD Lawrence, David G Norris, Floris P de Lange
    Neural activity in the visual system is increased in different layers of the neocortex for bottom-up and top-down modulations.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation

    Chee Wai Chua, Nusrat J Epsi ... Michael M Shen
    Analyses of genetically engineered mouse models reveal the androgen receptor-independent properties of a luminal stem/progenitor cell in the prostate epithelium, and its ability to serve as a cell of origin for castration-resistant prostate cancer.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    OpenNucleome for high-resolution nuclear structural and dynamical modeling

    Zhuohan Lao, Kartik D Kamat ... Bin Zhang
    An open-source tool for computational simulations of the human genome has been introduced, enabling the characterization of complex nuclear environments and the interpretation of experimental observations.
    1. Developmental Biology
    2. Neuroscience

    Pioneer neurog1 expressing cells ingress into the otic epithelium and instruct neuronal specification

    Esteban Hoijman, L Fargas ... Berta Alsina
    Quantitative 4D image analysis identifies a group of cells which enter into the otic primordium during morphogenesis and instructs neuronal specification.
    1. Neuroscience

    DMT alters cortical travelling waves

    Andrea Alamia, Christopher Timmermann ... Robin L Carhart-Harris
    Psychedelics induce a pattern of cortical activity very similar to the one observed during visual perception, despite participants had shut eyes.
    1. Biochemistry and Chemical Biology

    Fatal amyloid formation in a patient’s antibody light chain is caused by a single point mutation

    Pamina Kazman, Marie-Theres Vielberg ... Johannes Buchner
    Identifying the patient-specific mutation that shifted the antibody light chain to the deadly fibrillar species provides new insight in the molecular pathogenesis of AL amyloidosis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

    Pei-Ling Tsai, Chenguang Zhao ... Christian Schlieker
    Lamin B receptor may provide a long-sought model system enabling unprecedented studies of protein quality control in the nuclear envelope of mammalian cells.
    1. Developmental Biology

    Notch signaling and Bsh homeodomain activity are integrated to diversify Drosophila lamina neuron types

    Chundi Xu, Tyler B Ramos ... Chris Q Doe
    Notch signaling specifies binary neuronal fates through its integration with primary homeodomain activity.
    1. Genetics and Genomics

    The rise and fall of the Phytophthora infestans lineage that triggered the Irish potato famine

    Kentaro Yoshida, Verena J Schuenemann ... Hernán A Burbano
    The strain of Phytophthora infestans that caused the Great Famine in the late 1840s was caused by a single genotype that is distinct from, but closely related to, the most prevalent modern genotype.