1,567 results found
    1. Developmental Biology

    Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina

    Rana Amini, Archit Bhatnagar ... Caren Norden
    Horizontal cell undergoes amoeboid-like migration in the developing vertebrate retina, a not previously reported migration mode in the central nervous system, that allows them to move within a densely packed tissue without predetermined paths.
    1. Neuroscience

    Lamina-specific cortical dynamics in human visual and sensorimotor cortices

    James J Bonaiuto, Sofie S Meyer ... Sven Bestmann
    Cortical oscillations in human MEG are lamina-specific, with low-frequency activity predominating in deep, and high-frequency activity in more superficial layers of sensory and motor cortices.
    1. Cell Biology

    Novel origin of lamin-derived cytoplasmic intermediate filaments in tardigrades

    Lars Hering, Jamal-Eddine Bouameur ... Georg Mayer
    A newly discovered cytoplasmic intermediate filament in water bears may help these animals to resist extreme environmental conditions.
    1. Cell Biology

    LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

    Nana Naetar, Konstantina Georgiou ... Roland Foisner
    The lamin A/C binding protein LAP2α inhibits formation of higher order lamin structures in the nuclear interior in a lamin A/C-phosphorylation-independent manner, thereby regulating chromatin mobility.
    1. Cancer Biology
    2. Computational and Systems Biology

    Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction

    Sara Latini, Veronica Venafra ... Francesca Sacco
    Acute myeloid leukemia-specific predictive logic models reveal new therapeutic targets involved in cancer resistance mechanisms paving the way for personalized precision medicine.
    1. Cancer Biology
    2. Cell Biology

    Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs

    Saori Furuta, Gang Ren ... Mina J Bissell
    Endogenous laminins are necessary to build a functional acinus via generating NO, activating p53, HOXD10 and other positive players, but tumor cells neither make laminin nor generate NO, unless they are reverted to an organized structure.
    1. Neuroscience

    A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1

    Yi Bessie Liu, Ambika Tewari ... Kathleen J Sweadner
    A mouse with a defined mutation in an extracellular matrix protein that is expressed in selected neurons sheds light on circuit abnormalities producing transient hyperkinetic movements.
    1. Cell Biology

    The transcription factor Hey and nuclear lamins specify and maintain cell identity

    Naama Flint Brodsly, Eliya Bitman-Lotan ... Amir Orian
    Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.
    1. Neuroscience

    Dissociable laminar profiles of concurrent bottom-up and top-down modulation in the human visual cortex

    Samuel JD Lawrence, David G Norris, Floris P de Lange
    Neural activity in the visual system is increased in different layers of the neocortex for bottom-up and top-down modulations.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation

    Emma Carley, Rachel M Stewart ... Megan C King
    Forces stemming from cell-matrix adhesions, but not cell-cell adhesions, are directly transmitted to the nuclear lamina to regulate epidermal cell fate.

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