1,572 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

    David A Murphy, Eyal Elyashiv ... Guy Sella
    Background selection is shown to be the dominant mode of linked selection in humans, with marked effects on diversity levels throughout autosomes.
    1. Cell Biology

    A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics

    Etai Sapoznik, Bo-Jui Chang ... Reto P Fiolka
    A novel single-objective light-sheet microscope with unparalleled spatiotemporal resolution enables imaging and optical manipulation of diverse biological specimens and processes.
    1. Neuroscience

    Impaired voice processing in reward and salience circuits predicts social communication in children with autism

    Daniel Arthur Abrams, Aarthi Padmanabhan ... Vinod Menon
    Children with autism often 'tune out' the voices in their environment and new results show that impaired processing of voices in the brain's reward system may underlie this social behavior.
    1. Neuroscience

    The integrated brain network that controls respiration

    Friedrich Krohn, Manuele Novello ... Laurens WJ Bosman
    The primary rhythm generators controlling respiration are integrated in a much larger network of brain regions, including areas not typically considered to be respiratory control centers, and that allow respiration to be adapted to all forms of ongoing behavior.
    1. Genetics and Genomics
    2. Neuroscience

    Fruitless mutant male mosquitoes gain attraction to human odor

    Nipun S Basrur, Maria Elena De Obaldia ... Leslie B Vosshall
    Engineering male mosquitoes lacking the fruitless gene induces them to be attracted to humans.
    1. Neuroscience
    2. Computational and Systems Biology

    Testing the state-dependent model of subsecond time perception against experimental evidence

    Pirathitha Ravichandran-Schmidt, Joachim Hass
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva, Adrian Jacobo ... A J Hudspeth
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

    Roman O Fedoryshchak, Magdalena Přechová ... Richard Treisman
    Interaction of cofactor Phactr1 with PP1 creates a composite substrate-binding surface that defines the sequence specificity of the Phactr1/PP1 holoenzyme.
    1. Cell Biology
    2. Neuroscience

    Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis

    Luting Yang, Chunqing Hu ... Yaping Yan
    Cell biology and animal model analysis in mice shows that molecules involved in glycolytic metabolism could potentially serve as therapeutic targets for the treatment of neurological diseases.

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