Andreas A Kardamakis, Juan Pérez-Fernández, Sten Grillner
Signals conveyed from two different senses from a given point in space converge onto the same neurons of the optic tectum that trigger the gaze-control-system, and at the same time inhibit other parts of the tectal motor map.
Several key functional features of jawed vertebrate rods are also present in lamprey photoreceptors, indicating that our Cambrian ancestors possessed dim light vision.
Expansion microscopy combined with light-sheet and STED microscopy elucidated the spatial organization and subcellular composition of two distinct GABAergic CSF-c neuronal subtypes in the lamprey spinal cord.
Experimentally validated structural models of ACKR1-LukE and CCR5-LukE complexes reveal the critical contributions of sulfotyrosine binding sites and divergent loops of Staphylococcus aureus leukotoxins to the recognition of chemokine receptors.
Embryonic fate-mapping approaches in zebrafish, Xenopus and lamprey illuminate the evolutionary origins of carotid body glomus cells and pulmonary neuroendocrine cells.
Proteomic, biochemical and cell-based analyses of the heterodecameric core GID/CTLH E3 ligase complex reveal its molecular architecture, activity determinants, and function in targeting the tumor suppressor Hbp1 and other substrates required for cell proliferation.
By controlling the SUMOylation of the protein CAR-1, the aging-regulating pathways downstream of the Insulin/IGF signaling cascade and of the germ cells of the nematode Caenorhabditis elegans are integrated.