220 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity

    Meghan O Altman, Jack R Bennink ... Brantley R Herrin
    Antibody responses are remarkably similar in widely disparate hosts.
    1. Neuroscience

    Spatiotemporal interplay between multisensory excitation and recruited inhibition in the lamprey optic tectum

    Andreas A Kardamakis, Juan Pérez-Fernández, Sten Grillner
    Signals conveyed from two different senses from a given point in space converge onto the same neurons of the optic tectum that trigger the gaze-control-system, and at the same time inhibit other parts of the tectal motor map.
    1. Neuroscience

    A Cambrian origin for vertebrate rods

    Sabrina Asteriti, Sten Grillner, Lorenzo Cangiano
    Several key functional features of jawed vertebrate rods are also present in lamprey photoreceptors, indicating that our Cambrian ancestors possessed dim light vision.
    1. Neuroscience

    ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the lamprey central canal

    Elham Jalalvand, Jonatan Alvelid ... Ilaria Testa
    Expansion microscopy combined with light-sheet and STED microscopy elucidated the spatial organization and subcellular composition of two distinct GABAergic CSF-c neuronal subtypes in the lamprey spinal cord.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins

    Paul Lambey, Omolade Otun ... Cédric Leyrat
    Experimentally validated structural models of ACKR1-LukE and CCR5-LukE complexes reveal the critical contributions of sulfotyrosine binding sites and divergent loops of Staphylococcus aureus leukotoxins to the recognition of chemokine receptors.
    1. Neuroscience

    Neural mechanisms underlying expectation-dependent inhibition of distracting information

    Dirk van Moorselaar, Eline Lampers ... Heleen A Slagter
    Learned expectations allow for a distinct anticipatory distractor representation at the feature but not at the spatial level.
    1. Developmental Biology

    Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

    Dorit Hockman, Alan J Burns ... Clare V H Baker
    Embryonic fate-mapping approaches in zebrafish, Xenopus and lamprey illuminate the evolutionary origins of carotid body glomus cells and pulmonary neuroendocrine cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation

    Fabienne Lampert, Diana Stafa ... Matthias Peter
    Proteomic, biochemical and cell-based analyses of the heterodecameric core GID/CTLH E3 ligase complex reveal its molecular architecture, activity determinants, and function in targeting the tumor suppressor Hbp1 and other substrates required for cell proliferation.
    1. Cell Biology
    2. Neuroscience

    The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans

    Lorna Moll, Noa Roitenberg ... Ehud Cohen
    By controlling the SUMOylation of the protein CAR-1, the aging-regulating pathways downstream of the Insulin/IGF signaling cascade and of the germ cells of the nematode Caenorhabditis elegans are integrated.
    1. Cancer Biology

    Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations

    Denise Chroscinski, Darryl Sampey ... Reproducibility Project: Cancer Biology

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